Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 13/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 12/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 3/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24933208 | 0.84 | KMT2A (0.40) | HSD17B1HSD17B2BTK | |
| SCHEMBL24933771 | 0.84 | IKBKB (0.42) | HSD17B1HSD17B2CDK5CDK5R1PARP1 | |
| SCHEMBL24933189 | 0.81 | HSD17B1 (0.39) | HSD17B1HSD17B2CDK5CDK5R1PARP1 | |
| SCHEMBL24933797 | 0.81 | PARP1 (0.44) | HSD17B1HSD17B2PARP1PARP2MAPK8 | |
| SCHEMBL24933359 | 0.80 | HSD17B2 (0.50) | HSD17B1HSD17B2BTK | |
| SCHEMBL24933350 | 0.79 | RXRA (0.37) | HSD17B1HSD17B2CDK5CDK5R1MAPK8 | |
| SCHEMBL24933605 | 0.79 | HSD17B2 (0.41) | HSD17B1HSD17B2PARP1 | |
| SCHEMBL24933312 | 0.79 | BTK (0.42) | HSD17B1HSD17B2CDK5HDAC6MAPK8 | |
| SCHEMBL24933339 | 0.78 | HSD17B1 (0.41) | HSD17B1HSD17B2CDK5CDK5R1PARP1 | |
| SCHEMBL24932950 | 0.77 | HSD17B2 (0.52) | HSD17B1HSD17B2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | disclosed |