Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 9/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.36 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24933632 | 0.83 | DRD4 (0.38) | NPBWR1SMN1; SMN2MCHR1PDE1BPDE1C | |
| SCHEMBL30240868 | 0.79 | NPBWR1 (0.42) | NPBWR1SMN1; SMN2MCHR1PDE1BPDE1C | |
| SCHEMBL24933635 | 0.71 | NPBWR1 (0.44) | NPBWR1SMN1; SMN2MCHR1UCHL1SIGMAR1 | |
| SCHEMBL24933626 | 0.71 | NPBWR1 (0.50) | NPBWR1SMN1; SMN2MCHR1UCHL1PDE1B | |
| SCHEMBL29203463 | 0.71 | NPBWR1 (0.39) | NPBWR1SMN1; SMN2MCHR1PDE1BPDE1C | |
| SCHEMBL25521015 | 0.70 | NPBWR1 (0.43) | NPBWR1MCHR1UCHL1CNR2ALDH1A1 | |
| SCHEMBL29967137 | 0.68 | NPBWR1 (0.43) | NPBWR1SMN1; SMN2MCHR1SIGMAR1ALDH1A1 | |
| SCHEMBL25521029 | 0.68 | NPBWR1 (0.43) | NPBWR1MCHR1UCHL1PDE1BPDE1C | |
| SCHEMBL24588024 | 0.68 | LMNA (0.42) | NPBWR1MCHR1UCHL1CNR2 | |
| SCHEMBL31549279 | 0.65 | PTGER4 (0.44) | SMN1; SMN2UCHL1ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373809-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | Novartis AG (CH) | 2024-05-29 | — | — | EP | disclosed |
| CN-117980292-A | Substituted pyridone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | disclosed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | disclosed |