SCHEMBL24935781

SCHEMBL24935781

CC(=O)COCC(F)(F)CCOc1ccc(C)cc1F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MRGPRX4 Q96LA9 1/20 0.41
TSHR P16473 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
CYP2C9 P11712 2/20 0.36
TDP1 Q9NUW8 2/20 0.36
TTR P02766 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C8 P10632 1/20 0.36
CHRM1 P11229 1/20 0.36
ADRA1A P35348 1/20 0.36
PPARG P37231 1/20 0.36
HTR2B P41595 1/20 0.36
PPARA Q07869 1/20 0.36
SLCO1B3 Q9NPD5 1/20 0.36
CISD1 Q9NZ45 1/20 0.36
SLCO1B1 Q9Y6L6 1/20 0.36
FFAR1 O14842 4/20 0.36
L3MBTL1 Q9Y468 2/20 0.34
LMNA P02545 1/20 0.34
MAPT P10636 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24935607 0.90 MRGPRX4 (0.41) MRGPRX4TSHRSMN1; SMN2CYP2C9TDP1
SCHEMBL24935653 0.82 MAPT (0.36) MRGPRX4TSHRSMN1; SMN2CYP2C9TDP1
SCHEMBL24935148 0.81 L3MBTL1 (0.45) CYP2C9CYP1A2PPARAL3MBTL1LMNA
SCHEMBL24935659 0.76 MRGPRX4 (0.44) MRGPRX4TSHRSMN1; SMN2FFAR1L3MBTL1
SCHEMBL24935609 0.75 FFAR1 (0.37) MRGPRX4FFAR1L3MBTL1ALDH1A1
SCHEMBL25063899 0.74 FFAR1 (0.37) MRGPRX4FFAR1L3MBTL1
SCHEMBL24935230 0.73 MRGPRX4 (0.46) MRGPRX4FFAR1PTGDR2
SCHEMBL24934755 0.73 MRGPRX4 (0.41) MRGPRX4SMN1; SMN2FFAR1L3MBTL1LMNA
SCHEMBL20207970 0.72 MRGPRX4 (0.43) MRGPRX4TSHRSMN1; SMN2CYP2C9TDP1
SCHEMBL15004597 0.71 APP (0.43) MRGPRX4TSHRSMN1; SMN2CYP2C9TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230054270-A1 BIFUNCTIONAL COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF SUZHOU KINTOR PHARMACEUTICALS, INC. (CN) 2023-02-23 US disclosed
EP-4119546-A1 BIFUNCTIONAL COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF Suzhou Kintor Pharmaceuticals, Inc. (CN) 2023-01-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230054270-A1 BIFUNCTIONAL COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF AR, SHBG, NR5A1 MRGPRX4 3632/4885TSHR 2263/4885SMN1; SMN2 4819/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.