⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL7667190 | 0.87 | LMNA (0.64) | — | |
| SCHEMBL6888664 | 0.82 | — | — | |
| Succinic Acid SCHEMBL7619170 | 0.79 | LMNA (0.75) | — | |
| Succinic Acid SCHEMBL18604000 | 0.79 | LMNA (0.75) | — | |
| Succinic Acid SCHEMBL6888987 | 0.79 | LMNA (0.75) | — | |
| Succinic Acid SCHEMBL6888985 | 0.79 | LMNA (0.75) | — | |
| SCHEMBL4969205 | 0.79 | — | — | |
| SCHEMBL10456046 | 0.78 | — | — | |
| Succinic Acid SCHEMBL2455009 | 0.76 | LMNA (0.69) | — | |
| Succinic Acid SCHEMBL28141690 | 0.76 | LMNA (0.69) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1126833-A4 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES INC (US) | 2004-09-08 | — | — | EP | claimed |
| EP-1126833-A2 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2001-08-29 | — | — | EP | claimed |
| WO-2000025768-A1 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2000-05-11 | — | — | WO | claimed |
| WO-2022100710-A1 | TYROSINE KINASE 2 (TYK2) DEGRADATION COMPOUNDS AND METHODS OF USE | CULLGEN (SHANGHAI) , INC. (CN) | 2022-05-19 | — | — | WO | disclosed |
| US-8029979-B2 | Method for determining the substrate specificity of an enzyme | JPT PEPTIDE TECHNOLOGIES GMBH (DE) | 2011-10-04 | — | — | US | disclosed |
| US-20060234308-A1 | Method for determining the substrate specificity of an enzymatic activity and a device therefor | JERINI AG (DE) | 2006-10-19 | — | — | US | disclosed |
| US-20040171097-A1 | Method for determining the substrate specificity of an enzymatic activity and a device therefor | JERINI AG (DE) | 2004-09-02 | — | — | US | disclosed |
| WO-1999048911-A1 | MONOBACTAM ENZYME INHIBITORS | NAEJA PHARMACEUTICAL INC. (GB) | 1999-09-30 | — | — | WO | disclosed |
| EP-0668857-A1 | PROCESS FOR THE PREPARATION OF TRIAZOLONE COMPOUNDS | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (IT) | 1995-08-30 | — | — | EP | disclosed |
| WO-1994011357-A1 | PROCESS FOR THE PREPARATION OF TRIAZOLONE COMPOUNDS | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO (A.C.R.A.F.) S.P.A. (IT) | 1994-05-26 | — | — | WO | disclosed |