Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 2/20 | 0.41 |
| ▸ | CDK8 | P49336 | 2/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 7/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206302 | 1.00 | CCNC (0.41) | CCNCCDK8PDGFRASYKFLT3 | |
| SCHEMBL24943838 | 0.93 | TBK1 (0.46) | FLT3TNIKTBK1IKBKE | |
| SCHEMBL30205580 | 0.93 | TBK1 (0.46) | FLT3TNIKTBK1IKBKE | |
| SCHEMBL29173544 | 0.92 | CCNC (0.41) | CCNCCDK8PDGFRAFLT3EGFR | |
| SCHEMBL30205579 | 0.90 | SYK (0.44) | CCNCCDK8PDGFRASYKFLT3 | |
| SCHEMBL24944183 | 0.90 | SYK (0.44) | CCNCCDK8PDGFRASYKFLT3 | |
| SCHEMBL24944972 | 0.89 | EML4 (0.45) | SYKFLT3AURKACDK2 | |
| SCHEMBL30206232 | 0.89 | EML4 (0.45) | SYKFLT3AURKACDK2 | |
| SCHEMBL29173605 | 0.85 | IKBKE (0.38) | SYKFLT3TBK1IKBKEAURKA | |
| SCHEMBL24944792 | 0.83 | CAMK2D (0.40) | CCNCCDK8PDGFRASYKFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |