SCHEMBL24947724

SCHEMBL24947724

N#Cc1ccc(SN2CCCCC2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 6/20 0.50
MAOB P27338 6/20 0.50
HRH3 Q9Y5N1 6/20 0.44
CYP11B1 P15538 1/20 0.41
CYP11B2 P19099 1/20 0.41
KDM4E B2RXH2 2/20 0.39
KCNJ1 P48048 1/20 0.39
KCNH2 Q12809 1/20 0.39
TP53 P04637 1/20 0.39
HRH2 P25021 1/20 0.38
HRH1 P35367 1/20 0.38
ALDH1A1 P00352 2/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
CYP2A6 P11509 1/20 0.37
CA12 O43570 1/20 0.37
CA2 P00918 1/20 0.37
CA3 P07451 1/20 0.37
CA6 P23280 1/20 0.37
CA9 Q16790 1/20 0.37
CA14 Q9ULX7 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24938154 0.81 AR (0.46) MAOAMAOBHRH3KDM4EKCNJ1
SCHEMBL18582856 0.78 DRD2 (0.42) HRH3
SCHEMBL446306 0.75 MGLL (0.35) ALDH1A1
SCHEMBL19903237 0.75 HPGD (0.38) MAOAMAOBKDM4EALDH1A1L3MBTL1
SCHEMBL24894074 0.75 KMT2A (0.38) HRH3KDM4ETP53ALDH1A1
SCHEMBL24124260 0.75 ALDH1A1 (0.47) KDM4ETP53ALDH1A1L3MBTL1
SCHEMBL4872049 0.74 ALDH1A1 (0.53) KCNH2ALDH1A1
SCHEMBL19159879 0.73 USP2 (0.40) MAOAMAOBKCNH2ALDH1A1
SCHEMBL19903214 0.72 HPGD (0.39) MAOAMAOBALDH1A1L3MBTL1CYP2A6
SCHEMBL15721254 0.72 MAPK1 (0.44) KDM4ETP53ALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023007147-A1 6-SUBSTITUTED NAPHTHALENE-1,3-DISULFONIC ACID DERIVATIVES AS MODULATORS OF THE EXTRACELLULAR NICOTINAMIDE PHOSPHORIBOSYL TRANSFERASE (ENAMPT) FOR THE TREATMENT OF E.G. DIABETES THE UNIVERSITY OF MANCHESTER (GB) 2023-02-02 WO disclosed