Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 6/20 | 0.34 |
| ▸ | RAB9A | P51151 | 6/20 | 0.34 |
| ▸ | HTT | P42858 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | GALR3 | O60755 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL861630 | 0.80 | SLC9A1 (0.40) | SLC9A1NPC1RAB9AHTTLMNA | |
| SCHEMBL16815457 | 0.78 | SLC9A1 (0.39) | SLC9A1MAPK1MPOTLR8CYP1A2 | |
| SCHEMBL16861288 | 0.75 | SLC9A1 (0.37) | SLC9A1ALDH1A1MAPK1HSP90AA1MPO | |
| SCHEMBL9628160 | 0.74 | CNR1 (0.34) | SLC9A1NPC1RAB9AHTTLMNA | |
| SCHEMBL4563226 | 0.74 | SLC9A1 (0.40) | SLC9A1NPC1RAB9AHTTLMNA | |
| SCHEMBL10892388 | 0.74 | NPC1 (0.39) | NPC1RAB9AHTTLMNAAPOBEC3A | |
| SCHEMBL13500287 | 0.74 | SLC9A1 (0.39) | SLC9A1ALDH1A1POLBMAPK1MAPT | |
| SCHEMBL10376502 | 0.74 | MAPK1 (0.40) | SLC9A1RAB9AHTTLMNAGALR3 | |
| SCHEMBL22347413 | 0.73 | — | — | |
| SCHEMBL4553490 | 0.73 | MAPK1 (0.44) | HTTLMNAALDH1A1MAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 115 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104334534-B | Improved process for preparing 1-aryl-5-alkylpyrazole compounds | 勃林格殷格翰动物保健美国公司 | 2020-01-10 | — | — | CN | claimed |
| CN-110452174-A | Improved process for preparing 1-aryl-5-alkylpyrazole compounds | MERIAL LTD | 2019-11-15 | — | — | CN | claimed |
| EP-3184510-B1 | IMPROVED PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | MERIAL INC (US) | 2019-06-12 | — | — | EP | claimed |
| EP-3184510-A1 | IMPROVED PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | Merial, Inc. (US) | 2017-06-28 | — | — | EP | claimed |
| US-9273007-B2 | Processes for the preparation of 1-aryl-5-alkyl pyrazole compounds | MERIAL, INC. (US) | 2016-03-01 | — | — | US | claimed |
| EP-2035390-B1 | 1-Aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | MERIAL INC (US) | 2015-12-09 | — | — | EP | claimed |
| EP-2852577-A2 | IMPROVED PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | Merial Limited (US) | 2015-04-01 | — | — | EP | claimed |
| US-20150073153-A1 | PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | MERIAL LIMITED (US) | 2015-03-12 | — | — | US | claimed |
| CN-104334534-A | Improved process for preparing 1-aryl-5-alkylpyrazole compounds | MERIAL LTD | 2015-02-04 | — | — | CN | claimed |
| US-8937185-B2 | Processes for the preparation of 1-aryl-5-alkyl pyrazole compounds | MERIAL LIMITED (US) | 2015-01-20 | — | — | US | claimed |
| CN-103483260-A | 1-aryl-5-alkylpyrazole derivative compounds, methods of making and methods of use thereof | AVENTIS AGRICULTURE | 2014-01-01 | — | — | CN | claimed |
| US-20130281710-A1 | PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | MERIAL LIMITED (US) | 2013-10-24 | — | — | US | claimed |
| WO-2013159094-A2 | IMPROVED PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | MERIAL LIMITED (US) | 2013-10-24 | — | — | WO | claimed |
| CN-101511795-B | 1-aryl-5-alkylpyrazole derivative compounds, methods of making and methods of use thereof | AVENTIS AGRICULTURE | 2013-09-18 | — | — | CN | claimed |
| EP-2465851-A1 | 1-Aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | Aventis Agriculture (FR) | 2012-06-20 | — | — | EP | claimed |
| US-7759381-B2 | 1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | AVENTIS AGRICULTURE (FR) | 2010-07-20 | — | — | US | claimed |
| CN-101511795-A | 1-aryl-5-alkylpyrazole derivative compounds, methods of making and methods of use thereof | AVENTIS AGRICULTURE (FR) | 2009-08-19 | — | — | CN | claimed |
| EP-2035390-A2 | 1-ARYL-5-ALKYL PYRAZOLE DERIVATIVE COMPOUNDS, PROCESSES OF MAKING AND METHODS OF USING THEREOF | Aventis Agriculture (FR) | 2009-03-18 | — | — | EP | claimed |
| US-20080031902-A1 | 1-Aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | MERIAL, INC. | 2008-02-07 | — | — | US | claimed |
| WO-2008005489-A2 | 1-ARYL-5-ALKYL PYRAZOLE DERIVATIVE COMPOUNDS, PROCESSES OF MAKING AND METHODS OF USING THEREOF | AVENTIS AGRICULTURE (FR) | 2008-01-10 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150073153-A1 | PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | SULT1A1, CYP1B1, CYP2F1 | SLC9A1 2745/4885NPC1 3268/4885RAB9A 1074/4885 |
| US-20080031902-A1 | 1-Aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | CBR3, CBR1, NR5A2 | SLC9A1 617/4885NPC1 846/4885RAB9A 828/4885 |
| US-20130281710-A1 | PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | SULT1A1, CYP1B1, CYP2F1 | SLC9A1 2745/4885NPC1 3268/4885RAB9A 1074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.