SCHEMBL4553490

SCHEMBL4553490

CCCCCn1nccc1CC(=O)O

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.44
ALDH1A1 P00352 2/20 0.42
HCAR3 P49019 2/20 0.41
CDC25A P30304 1/20 0.41
HPGD P15428 1/20 0.40
HSD17B10 Q99714 1/20 0.40
KDM5A P29375 1/20 0.39
KDM5B Q9UGL1 1/20 0.39
SMPD1 P17405 1/20 0.38
PTGIR P43119 2/20 0.36
KDM4E B2RXH2 1/20 0.36
LMNA P02545 1/20 0.36
HTT P42858 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
CNR1 P21554 1/20 0.36
CNR2 P34972 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16815457 0.80 SLC9A1 (0.39) MAPK1HCAR3KDM5AKDM5BCNR1
SCHEMBL861630 0.78 SLC9A1 (0.40) ALDH1A1HPGDHSD17B10KDM5AKDM5B
SCHEMBL1987942 0.78 HCAR3 (0.46) MAPK1ALDH1A1HCAR3HPGDKDM5A
SCHEMBL16861288 0.78 SLC9A1 (0.37) MAPK1ALDH1A1HCAR3HPGDHSD17B10
SCHEMBL16815266 0.75 SLC9A1 (0.38) MAPK1ALDH1A1HCAR3KDM5AKDM5B
SCHEMBL2774684 0.74 KMT2A (0.51) MAPK1HTT
SCHEMBL11499176 0.74 SLC9A1 (0.42) MAPK1ALDH1A1HCAR3LMNAHTT
SCHEMBL4563226 0.73 SLC9A1 (0.40) ALDH1A1HPGDHSD17B10KDM4ELMNA
SCHEMBL2494852 0.73 SLC9A1 (0.36) MAPK1ALDH1A1KDM4ELMNAHTT
SCHEMBL13500287 0.73 SLC9A1 (0.39) MAPK1ALDH1A1HCAR3KDM5AKDM5B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2121621-B1 LXR AND FXR MODULATORS EXELIXIS PATENT CO LLC (US) 2014-05-07 EP disclosed
EP-2121621-A1 LXR AND FXR MODULATORS Exelixis, Inc. (US) 2009-11-25 EP disclosed
WO-2008073825-A1 LXR AND FXR MODULATORS EXELIXIS, INC. (US) 2008-06-19 WO disclosed