Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.50 |
| ▸ | RELA | Q04206 | 3/20 | 0.50 |
| ▸ | JUN | P05412 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22145717 | 0.90 | MAPT (0.54) | RAB9ANPC1SMN1; SMN2MAPTNFKB1 | |
| SCHEMBL24952254 | 0.84 | RAB9A (0.47) | RAB9ALMNATSHRHSD17B10NPC1 | |
| SCHEMBL24951630 | 0.81 | ALDH1A1 (0.50) | RAB9ALMNANPC1SMN1; SMN2KDM4E | |
| SCHEMBL30202869 | 0.81 | ALDH1A1 (0.50) | RAB9ALMNANPC1SMN1; SMN2KDM4E | |
| SCHEMBL20558428 | 0.78 | NFKB1 (0.65) | KDM4EMAPTNFKB1NFKB2RELA | |
| SCHEMBL2949398 | 0.77 | RXFP1 (0.51) | RAB9ANPC1NFKB1NFKB2RELA | |
| SCHEMBL22145716 | 0.76 | NPC1 (0.50) | RAB9ANPC1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL22145723 | 0.75 | BRAF (0.67) | — | |
| SCHEMBL22145341 | 0.74 | KMT2A (0.45) | KDM4EMAPTNFKB1NFKB2RELA | |
| SCHEMBL22807419 | 0.74 | CHRNA7 (0.54) | MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023007009-A1 | PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-02-02 | — | — | WO | disclosed |