Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.46 |
| ▸ | RELA | Q04206 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22145716 | 0.92 | NPC1 (0.50) | RAB9ANPC1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL24951632 | 0.84 | RAB9A (0.52) | RAB9ALMNATSHRHSD17B10NPC1 | |
| SCHEMBL30202682 | 0.83 | ALDH1A1 (0.46) | RAB9ALMNANPC1KDM4EMAPT | |
| SCHEMBL24951831 | 0.83 | ALDH1A1 (0.46) | RAB9ALMNANPC1KDM4EMAPT | |
| SCHEMBL20558385 | 0.82 | RXFP1 (0.46) | NFKB1NFKB2RELAMAPK1POLB | |
| SCHEMBL20558515 | 0.82 | NFKB1 (0.54) | KDM4EMAPTNFKB1NFKB2RELA | |
| SCHEMBL22145342 | 0.78 | F10 (0.41) | RAB9ANPC1SMN1; SMN2KDM4ENFKB1 | |
| SCHEMBL20558390 | 0.78 | XPO1 (0.58) | RAB9ALMNATSHRNPC1SMN1; SMN2 | |
| SCHEMBL31737724 | 0.78 | PDE4D (0.42) | — | |
| SCHEMBL22145719 | 0.77 | NFKB1 (0.48) | RAB9ANPC1MAPTNFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023007009-A1 | PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-02-02 | — | — | WO | disclosed |