Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24954317 | 0.87 | MAP4K1 (0.41) | GPR119MAP4K1ESR2 | |
| SCHEMBL30215942 | 0.84 | PTPN11 (0.45) | GPR119MAP4K1NR1H2NR1H3USP30 | |
| SCHEMBL29216553 | 0.84 | PTPN11 (0.45) | GPR119MAP4K1NR1H2NR1H3USP30 | |
| SCHEMBL30893060 | 0.84 | PTPN11 (0.45) | GPR119MAP4K1NR1H2NR1H3USP30 | |
| SCHEMBL24954373 | 0.81 | MAP4K1 (0.51) | MAP4K1CYP11B2 | |
| SCHEMBL24954494 | 0.76 | MAP4K1 (0.43) | GPR119MAP4K1 | |
| SCHEMBL30893064 | 0.74 | MAP4K1 (0.39) | GPR119MAP4K1 | |
| SCHEMBL30215951 | 0.74 | MAP4K1 (0.39) | GPR119MAP4K1 | |
| SCHEMBL29216559 | 0.74 | MAP4K1 (0.39) | GPR119MAP4K1 | |
| SCHEMBL30893066 | 0.73 | PTPN11 (0.42) | MAP4K1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006063-A1 | PYRROLO [2, 3-b] PYRAZINE-BASED BIFUNCTIONAL COMPOUNDS AS HPK1 DEGRADERS AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2023-02-02 | — | — | WO | disclosed |