Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 2/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.34 |
| ▸ | CYP3A7 | P24462 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24956329 | 0.87 | PIM1 (0.43) | KDM5BKDM5ACHRNB2CHRNA4JAK2 | |
| SCHEMBL24956350 | 0.80 | FLT3 (0.43) | KDM5BPIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL24958873 | 0.79 | HDAC6 (0.41) | KDM5BPIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL24956347 | 0.78 | KDM5B (0.40) | KDM5BPIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL24958876 | 0.76 | KDM5B (0.48) | KDM5BPIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL24956527 | 0.73 | ACHE (0.33) | KDM5BPIK3CDPIK3CAPI4KAPIK3CG | |
| SCHEMBL17806588 | 0.71 | PIK3CD (0.46) | KDM5BPIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL21610561 | 0.69 | ALDH1A1 (0.31) | — | |
| SCHEMBL24958703 | 0.68 | NTRK1 (0.41) | KDM5BCHRNB2CHRNA4JAK2IRAK4 | |
| SCHEMBL24956356 | 0.65 | KDM5B (0.34) | KDM5BPIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230021705-A1 | GLP-1R MODULATING COMPOUNDS | GILEAD SCIENCES, INC. | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230021705-A1 | GLP-1R MODULATING COMPOUNDS | GLP1R, GIPR, GPR119 | KDM5B 2572/4885PIK3CD 778/4885PIK3CA 698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.