Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ESRRA | P11474 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 5/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 5/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 5/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16728864 | 0.79 | TAS1R3 (0.49) | EPHX2NR1H4PKMHTTMEN1 | |
| SCHEMBL30665778 | 0.77 | CYP2D6 (0.42) | EPHX2NR1H4PKMESRRAHTT | |
| SCHEMBL17831661 | 0.77 | CYP2D6 (0.42) | EPHX2NR1H4PKMESRRAHTT | |
| SCHEMBL16899217 | 0.77 | EPHX2 (0.55) | EPHX2NR1H4HTTMEN1LMNA | |
| SCHEMBL15492066 | 0.76 | PKM (0.44) | EPHX2NR1H4PKMHTTMEN1 | |
| SCHEMBL4814551 | 0.75 | PKM (0.43) | EPHX2NR1H4PKMHTTMEN1 | |
| SCHEMBL4810977 | 0.75 | PKM (0.47) | EPHX2NR1H4PKMHTTMEN1 | |
| SCHEMBL4090026 | 0.73 | HPGD (0.44) | PKMHTTMEN1LMNAMAPT | |
| SCHEMBL313146 | 0.73 | KIF11 (0.54) | ESRRAPDK1MRGPRX4MAOAMAOB | |
| SCHEMBL15352043 | 0.71 | MRGPRX4 (0.52) | ESRRAHTTMEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023288253-A1 | SMALL MOLECULES INHIBITORS OF CYCLIC GMP-AMP SYNTHASE (CGAS) | THE SCRIPPS RESEARCH INSTITUTE (US) | 2023-01-19 | — | — | WO | disclosed |