Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
| ▸ | GABRE | P78334 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.35 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.35 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13652380 | 0.72 | NOS2 (0.46) | GABRPGABRDGABRA1TSHRGABRB1 | |
| SCHEMBL13185830 | 0.71 | GNAI3 (0.39) | GABRPGABRDGABRA1TSHRGABRB1 | |
| SCHEMBL800703 | 0.70 | GABRA1 (0.41) | GABRPGABRDGABRA1TSHRGABRB1 | |
| SCHEMBL13652381 | 0.70 | GABRA1 (0.41) | GABRPGABRDGABRA1TSHRGABRB1 | |
| SCHEMBL8356925 | 0.66 | — | — | |
| SCHEMBL7513411 | 0.66 | CPN1 (0.46) | GABRA1TSHRGABRA5GABRB2GABRA4 | |
| SCHEMBL572489 | 0.66 | CPN1 (0.46) | GABRA1TSHRGABRA5GABRB2GABRA4 | |
| SCHEMBL20374425 | 0.65 | GABRP (0.37) | GABRPGABRDGABRA1TSHRGABRB1 | |
| SCHEMBL13451484 | 0.64 | GNAI3 (0.51) | GABRPGABRDGABRA1TSHRGABRB1 | |
| SCHEMBL31139892 | 0.64 | GNAI3 (0.51) | GABRPGABRDGABRA1TSHRGABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023288253-A1 | SMALL MOLECULES INHIBITORS OF CYCLIC GMP-AMP SYNTHASE (CGAS) | THE SCRIPPS RESEARCH INSTITUTE (US) | 2023-01-19 | — | — | WO | disclosed |