Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | MAOB | P27338 | 8/20 | 0.62 |
| ▸ | MAOA | P21397 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.57 |
| ▸ | CDK1 | P06493 | 1/20 | 0.57 |
| ▸ | CDK4 | P11802 | 1/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.57 |
| ▸ | CCND1 | P24385 | 1/20 | 0.57 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2496164 | 1.00 | ALDH1A1 (0.63) | ALDH1A1KDM4EPKMMAOBMAOA | |
| SCHEMBL9475742 | 0.86 | KDM4E (0.60) | ALDH1A1KDM4EPKMMAOBMAOA | |
| SCHEMBL9475746 | 0.86 | KDM4E (0.60) | ALDH1A1KDM4EPKMMAOBMAOA | |
| SCHEMBL12191876 | 0.86 | NR1H4 (0.62) | ALDH1A1KDM4EPKMMAOBMAOA | |
| SCHEMBL5606693 | 0.86 | NR1H4 (0.61) | KDM4EMAOBLCKNR4A2AKR1C3 | |
| SCHEMBL14198058 | 0.85 | MAOB (0.65) | ALDH1A1KDM4EPKMMAOBMAOA | |
| SCHEMBL3662418 | 0.84 | NR1H4 (0.63) | ALDH1A1KDM4EMAOBNR4A2AKR1C3 | |
| SCHEMBL3662420 | 0.84 | NR1H4 (0.63) | ALDH1A1KDM4EMAOBNR4A2AKR1C3 | |
| SCHEMBL21192732 | 0.84 | KDM4E (0.62) | ALDH1A1KDM4EMAOBMAOAMEN1 | |
| SCHEMBL3550677 | 0.84 | KDM4E (0.60) | ALDH1A1KDM4EPKMMAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030354-B2 | 2-(5,5-Dimethylcyclopent-1-enyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; metabolic disorders such as type II diabetes | AMGEN INC. (US) | 2011-10-04 | — | — | US | disclosed |
| EP-2205548-A1 | SUBSTITUTED BIPHENYL GPR40 MODULATORS | Amgen, Inc (US) | 2010-07-14 | — | — | EP | disclosed |
| US-20090137561-A1 | Substituted biphenyl GPR40 modulators | AMGEN INC. (US) | 2009-05-28 | — | — | US | disclosed |
| WO-2009048527-A1 | SUBSTITUTED BIPHENYL GPR40 MODULATORS | AMGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| US-20070173434-A1 | Antidiabetic oxazolidinediones and thiazolidinediones | MERCK SHARP & DOHME CORP. | 2007-07-26 | — | — | US | disclosed |
| EP-1709014-B1 | ANTIDIABETIC OXAZOLIDINEDIONES AND THIAZOLIDINEDIONES | MERCK & CO INC (US) | 2007-05-30 | — | — | EP | disclosed |
| EP-1709014-A1 | ANTIDIABETIC OXAZOLIDINEDIONES AND THIAZOLIDINEDIONES | Merck & Co., Inc. (US) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005070905-A1 | ANTIDIABETIC OXAZOLIDINEDIONES AND THIAZOLIDINEDIONES | MERCK & CO., INC. (US) | 2005-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137561-A1 | Substituted biphenyl GPR40 modulators | GPR119, GPR65, GPR55 | ALDH1A1 1149/4885KDM4E 2559/4885PKM 2037/4885 |
| US-20070173434-A1 | Antidiabetic oxazolidinediones and thiazolidinediones | PPARD, PPARA, PPARG | ALDH1A1 636/4885KDM4E 2385/4885PKM 948/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.