Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL249993 | 0.90 | NPC1 (0.43) | NPC1MAPK1OPRL1OPRM1RAB9A | |
| SCHEMBL206106 | 0.83 | OPRM1 (0.49) | LMNANPC1ALOX15TSHRMAPK1 | |
| SCHEMBL251293 | 0.77 | ENPP2 (0.42) | NPC1ALOX15MAPK1RAB9AALDH1A1 | |
| SCHEMBL250636 | 0.75 | LTA4H (0.52) | LMNANPC1RAB9AALDH1A1TDP1 | |
| SCHEMBL250548 | 0.75 | OPRM1 (0.48) | LMNATSHROPRL1OPRM1 | |
| SCHEMBL4075172 | 0.75 | LMNA (0.69) | LMNANPC1ALOX15TSHRMAPK1 | |
| SCHEMBL249977 | 0.75 | SMN1; SMN2 (0.46) | NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL249994 | 0.75 | NPC1 (0.45) | LMNANPC1OPRL1OPRM1MAPT | |
| SCHEMBL251283 | 0.75 | OPRM1 (0.44) | NPC1OPRL1OPRM1RAB9AALDH1A1 | |
| SCHEMBL250033 | 0.74 | OPRL1 (0.42) | NPC1OPRL1OPRM1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088763-B2 | e.g. N-[1-(2,6-dichloro-benzyl)-pyrrolidin-3-yl]-N'-[4-dimethylamino-4-(4-methyl-benzyl)-cyclohexyl]-succinamide; noradrenaline and serotonin reuptake ihibitor; opioid ORL-1 receptor ligand; analgesic, antidepressant, anxiolytic agent, neurodegenerative diseases | GRUENENTHAL GMBH (DE) | 2012-01-03 | — | — | US | disclosed |