Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 6/20 | 0.56 |
| ▸ | PRKCG | P05129 | 6/20 | 0.56 |
| ▸ | PRKCB | P05771 | 6/20 | 0.56 |
| ▸ | PRKCA | P17252 | 6/20 | 0.56 |
| ▸ | PRKCH | P24723 | 6/20 | 0.56 |
| ▸ | PRKCI | P41743 | 6/20 | 0.56 |
| ▸ | PRKCE | Q02156 | 6/20 | 0.56 |
| ▸ | PRKCQ | Q04759 | 6/20 | 0.56 |
| ▸ | PRKCZ | Q05513 | 6/20 | 0.56 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.56 |
| ▸ | PRKD1 | Q15139 | 6/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | PRKACA | P17612 | 4/20 | 0.56 |
| ▸ | PRKACG | P22612 | 4/20 | 0.56 |
| ▸ | PRKACB | P22694 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6967362 | 0.85 | CYP3A4 (0.59) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL29696494 | 0.82 | CYP3A4 (0.56) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL30075444 | 0.82 | CA1 (0.61) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL115053 | 0.82 | CYP3A4 (0.56) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL117745 | 0.82 | CYP3A4 (0.56) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL13677595 | 0.82 | CYP3A4 (0.58) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL1551138 | 0.82 | CA1 (0.61) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL29546384 | 0.82 | CYP3A4 (0.56) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| Hydrochloric Acid SCHEMBL8670953 | 0.81 | LMNA (0.57) | CYP3A4PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL8828469 | 0.81 | PRKD3 (0.61) | CYP3A4PRKD3PRKCGPRKCBPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030499-B2 | 1,3-dihydro-2H-indole-2-one compound and pyrrolidine-2-one compound fused with aromatic heterocycle | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-10-04 | — | — | US | disclosed |
| US-20080318923-A1 | 1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2008-12-25 | — | — | US | disclosed |
| WO-2005011697-A2 | SULFONAMIDE DERIVATIVES WITH ACTIVITY ON PROTEIN KINASE A AND B | ASTEX THERAPEUTICS LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318923-A1 | 1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle | AVPR1B, AVPR1A, AVPR2 | CYP3A4 1315/4885PRKD3 2788/4885PRKCG 2812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.