Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | LONP1 | P36776 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20061662 | 0.80 | ALDH1A1 (0.38) | KDM4EALDH1A1SMN1; SMN2NLRP3CYP1A2 | |
| SCHEMBL18462726 | 0.80 | KDM4E (0.38) | KDM4EALDH1A1SMN1; SMN2NLRP3CYP1A2 | |
| SCHEMBL510583 | 0.79 | KDM4E (0.40) | KDM4EALDH1A1SMN1; SMN2NLRP3CYP1A2 | |
| SCHEMBL29364563 | 0.79 | KDM4E (0.40) | KDM4EALDH1A1SMN1; SMN2NLRP3CYP1A2 | |
| SCHEMBL26085643 | 0.77 | KDM4E (0.43) | KDM4EALDH1A1SMN1; SMN2NLRP3CYP1A2 | |
| SCHEMBL11407471 | 0.76 | LMNA (0.37) | KDM4EALDH1A1SMN1; SMN2NLRP3CYP1A2 | |
| SCHEMBL4324227 | 0.76 | HRH4 (0.41) | KDM4EALDH1A1SMN1; SMN2NLRP3CYP1A2 | |
| SCHEMBL4685179 | 0.76 | KDM4E (0.38) | KDM4EALDH1A1SMN1; SMN2NLRP3CYP1A2 | |
| SCHEMBL30638522 | 0.76 | KDM4E (0.50) | KDM4EALDH1A1SMN1; SMN2NLRP3CYP1A2 | |
| SCHEMBL9474835 | 0.76 | KDM4E (0.50) | KDM4EALDH1A1SMN1; SMN2NLRP3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230022157-A1 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT FACTOR D MEDICAL DISORDERS | ACHILLION PHARMACEUTICALS, INC. (US) | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230022157-A1 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT FACTOR D MEDICAL DISORDERS | CFD, CFH, TFPI | KDM4E 4475/4885ALDH1A1 4494/4885SMN1; SMN2 4033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.