Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL615555 | 0.84 | MPO (0.38) | MAPTALDH1A1MEN1KMT2AHPGD | |
| Salicyluric Acid SCHEMBL29935452 | 0.71 | HPGD (0.58) | EGLN1MAPTALDH1A1MEN1KMT2A | |
| Salicyluric Acid SCHEMBL570541 | 0.71 | HPGD (0.58) | EGLN1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6363070 | 0.70 | ALDH1A1 (0.54) | MAPTALDH1A1MEN1KMT2AHPGD | |
| Iodohippurate SCHEMBL8073622 | 0.68 | KEAP1 (0.42) | EGLN1MEN1KMT2AKEAP1TDP1 | |
| SCHEMBL3389986 | 0.67 | HPGD (0.57) | MAPTALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL3423457 | 0.67 | EGLN1 (0.63) | EGLN1EGLN3EGLN2 | |
| SCHEMBL4952951 | 0.66 | LMNA (0.63) | MAPTALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL18589492 | 0.63 | LMNA (0.51) | — | |
| SCHEMBL31448014 | 0.63 | KEAP1 (0.62) | EGLN1MAPTKMT2AKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664327-B1 | METHODS OF SCREENING FOR COMPOUNDS THAT MODULATE TAFIa ACTIVITY, COMPOUNDS, AND METHODS OF USING THE COMPOUNDS | AMERICAN DIAGNOSTICA INC (US) | 2011-10-05 | — | — | EP | disclosed |