Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | LPL | P06858 | 7/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 7/20 | 0.34 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14758481 | 0.82 | AAK1 (0.40) | AAK1EGFRLPLLIPGSNCA | |
| SCHEMBL24252905 | 0.81 | AAK1 (0.41) | AAK1EGFRLPLLIPGDGAT1 | |
| SCHEMBL4578027 | 0.80 | AAK1 (0.39) | AAK1EGFRLPLLIPGSNCA | |
| SCHEMBL9910113 | 0.76 | PDE2A (0.44) | AAK1EGFRLPLLIPGCA1 | |
| SCHEMBL3025664 | 0.76 | LMNA (0.50) | AAK1EGFRLPLLIPGCA1 | |
| SCHEMBL2699826 | 0.76 | PDE2A (0.44) | AAK1EGFRLPLLIPGCA1 | |
| SCHEMBL2411421 | 0.75 | LPL (0.44) | AAK1EGFRLPLLIPGCA1 | |
| SCHEMBL2500684 | 0.74 | ESR1 (0.46) | — | |
| SCHEMBL2497862 | 0.74 | APLNR (0.46) | AAK1 | |
| SCHEMBL25314604 | 0.73 | AAK1 (0.39) | AAK1LPLLIPGDGAT1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030327-B2 | 3-[1-(2-chlorophenyl)ethoxy]-5-imidazo[1,2-a]pyridin-3-ylthiophene-2-carboxyamide; polo like kinase inhibitor; antitumor and anticarcinogenic agent; mitotic phase (M phase) of the cell cycle | MDS K.K. (JP) | 2011-10-04 | — | — | US | disclosed |