SCHEMBL24974644

SCHEMBL24974644

COc1ccc(OC)c(N2CC(C(=O)Nc3ccc(-c4cn(CC(C)(C)COCC(C)CC(=O)NCCN5C(=O)CC(SC6(C)CCCCCCCCCCCCCCC6)C5=O)nn4)cc3)CC2=O)c1

nearest known ligand 0.32

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 1/20 0.32
▸ POLB P06746 3/20 0.32
▸ SMN1; SMN2 Q16637 2/20 0.31
▸ USP2 O75604 2/20 0.30
▸ ALDH1A1 P00352 2/20 0.30
▸ GAA P10253 1/20 0.30
▸ MAPT P10636 1/20 0.30
▸ LMNA P02545 1/20 0.30
▸ HPGD P15428 1/20 0.30
▸ MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24974547 0.86 SMN1; SMN2 (0.35) POLBSMN1; SMN2USP2ALDH1A1GAA
SCHEMBL24974737 0.72 HDAC1 (0.42) POLBUSP2ALDH1A1MAPT
SCHEMBL24974573 0.72 HDAC1 (0.42) POLBUSP2ALDH1A1MAPT
SCHEMBL21152067 0.71 POLB (0.47) POLBSMN1; SMN2USP2ALDH1A1GAA
SCHEMBL24974592 0.69 ALDH1A1 (0.46) POLBSMN1; SMN2USP2ALDH1A1MAPT
SCHEMBL24974478 0.65 FOLH1 (0.30) —
SCHEMBL24974634 0.65 POLB (0.56) POLBSMN1; SMN2ALDH1A1MAPT
SCHEMBL24974541 0.64 ALDH1A1 (0.52) L3MBTL1POLBSMN1; SMN2USP2ALDH1A1
SCHEMBL24974742 0.62 MAPT (0.58) POLBALDH1A1MAPTLMNAMAPK1
SCHEMBL24974782 0.61 MAPT (0.58) POLBSMN1; SMN2USP2ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11572370-B2 CD16A binding agents and uses thereof BIOHAVEN THERAPEUTICS LTD. (US) 2023-02-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11572370-B2 CD16A binding agents and uses thereof FCGR1A, FCGR2A, FCGR3B L3MBTL1 1544/4885POLB 4058/4885SMN1; SMN2 3020/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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