SCHEMBL24974782

SCHEMBL24974782

CCCn1cc(-c2ccc(NC(=O)C3CC(=O)N(c4cccc(OC)c4)C3)cc2)nn1

nearest known ligand 0.58

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 0.58
▸ ALDH1A1 P00352 3/20 0.58
▸ GAA P10253 2/20 0.58
▸ USP2 O75604 1/20 0.58
▸ NPSR1 Q6W5P4 1/20 0.55
▸ POLB P06746 2/20 0.53
▸ KMT2A Q03164 4/20 0.51
▸ MEN1 O00255 1/20 0.51
▸ HTT P42858 3/20 0.49
▸ SMN1; SMN2 Q16637 2/20 0.49
▸ LMNA P02545 1/20 0.49
▸ HPGD P15428 1/20 0.48
▸ TSHR P16473 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24974742 0.92 MAPT (0.58) MAPTALDH1A1POLBKMT2AMEN1
SCHEMBL24974601 0.91 ROCK2 (0.54) MAPTALDH1A1GAAPOLBKMT2A
SCHEMBL21152067 0.88 POLB (0.47) MAPTALDH1A1GAAUSP2POLB
SCHEMBL24974634 0.86 POLB (0.56) MAPTALDH1A1POLBSMN1; SMN2
SCHEMBL24974541 0.82 ALDH1A1 (0.52) ALDH1A1USP2POLBHTTSMN1; SMN2
SCHEMBL24974637 0.81 KMT2A (0.48) MAPTALDH1A1GAANPSR1POLB
SCHEMBL24974592 0.79 ALDH1A1 (0.46) MAPTALDH1A1USP2POLBSMN1; SMN2
SCHEMBL5841673 0.77 MAPT (0.71) MAPTALDH1A1GAAUSP2NPSR1
SCHEMBL24974781 0.77 SIRT2 (0.48) —
SCHEMBL21151780 0.75 ROCK2 (0.45) MAPTALDH1A1GAAUSP2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11572370-B2 CD16A binding agents and uses thereof BIOHAVEN THERAPEUTICS LTD. (US) 2023-02-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11572370-B2 CD16A binding agents and uses thereof FCGR1A, FCGR2A, FCGR3B MAPT 4695/4885ALDH1A1 1203/4885GAA 553/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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