Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 13/20 | 0.38 |
| ▸ | TUBB | P07437 | 13/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 13/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 13/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 13/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 13/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 13/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 13/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 13/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 13/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 13/20 | 0.38 |
| ▸ | TUBA1C | Q9BQE3 | 13/20 | 0.38 |
| ▸ | TUBB6 | Q9BUF5 | 13/20 | 0.38 |
| ▸ | TUBB2B | Q9BVA1 | 13/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 13/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1879116 | 0.87 | CTSA (0.45) | CTSATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL2503114 | 0.86 | BACE1 (0.38) | TRPM8 | |
| SCHEMBL2501192 | 0.86 | CTSA (0.42) | CTSATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL2493409 | 0.85 | SCN9A (0.45) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL2495560 | 0.85 | HTR7 (0.42) | CTSATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL2495973 | 0.84 | SCN9A (0.41) | CTSATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL2498115 | 0.83 | CTSA (0.41) | CTSATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL2493819 | 0.83 | CTSA (0.42) | CTSATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL2498106 | 0.82 | TUBB4A (0.45) | CTSATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1886004 | 0.82 | NOTUM (0.53) | CTSATUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233929-A1 | Imidazole Derivatives for the Treatment of Anxiety and Related Diseases | NEUROSEARCH A/S (DK) | 2009-09-17 | — | — | US | claimed |
| US-8030339-B2 | Imidazole derivatives for the treatment of anxiety and related diseases | NEUROSEARCH A/S (DK) | 2011-10-04 | — | — | US | disclosed |
| US-20090233929-A1 | Imidazole Derivatives for the Treatment of Anxiety and Related Diseases | NEUROSEARCH A/S (DK) | 2009-09-17 | — | — | US | disclosed |
| EP-1937649-A1 | IMIDAZOLE DERIVATIVES FOR THE TREATMENT OF ANXIETY AND RELATED DISEASES | NEUROSEARCH A/S (DK) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007042546-A1 | IMIDAZOLE DERIVATIVES FOR THE TREATMENT OF ANXIETY AND RELATED DISEASES | NEUROSEARCH A/S (DK) | 2007-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233929-A1 | Imidazole Derivatives for the Treatment of Anxiety and Related Diseases | GABBR1, GABRB2, GABRB3 | CTSA 3719/4885TUBB4A 1647/4885TUBB 1023/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.