SCHEMBL24978427

SCHEMBL24978427

O=C(Nc1cnc(Cl)n2cnnc12)C1CCCO1

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ HSD17B10 Q99714 5/20 0.45
▸ KDM4E B2RXH2 4/20 0.45
▸ KMT2A Q03164 2/20 0.45
▸ TSHR P16473 1/20 0.45
▸ ALDH1A1 P00352 7/20 0.44
▸ HPGD P15428 3/20 0.44
▸ SMN1; SMN2 Q16637 4/20 0.43
▸ POLB P06746 1/20 0.42
▸ HTT P42858 1/20 0.42
▸ NPC1 O15118 1/20 0.41
▸ LMNA P02545 1/20 0.41
▸ RAB9A P51151 1/20 0.41
▸ TP53 P04637 1/20 0.41
▸ MAPK10 P53779 1/20 0.41
▸ MEN1 O00255 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24978421 0.97 CDK2 (0.42) HSD17B10KDM4EKMT2ATSHRALDH1A1
SCHEMBL23330649 0.83 HDAC3 (0.41) KMT2ATSHRALDH1A1HPGDSMN1; SMN2
SCHEMBL23331001 0.82 ALDH1A1 (0.39) KDM4EKMT2ATSHRALDH1A1SMN1; SMN2
SCHEMBL24978410 0.82 CETP (0.40) HSD17B10KDM4EKMT2ATSHRALDH1A1
SCHEMBL23300898 0.82 ACVRL1 (0.38) KMT2AALDH1A1HPGDSMN1; SMN2NPC1
SCHEMBL23331072 0.82 HDAC1 (0.41) HSD17B10KDM4EKMT2A
SCHEMBL24978675 0.80 NAMPT (0.38) POLBMAPK10
SCHEMBL23330489 0.76 MAPT (0.44) HSD17B10KDM4ETSHRALDH1A1HPGD
SCHEMBL23331246 0.74 P2RX7 (0.38) KDM4EKMT2AALDH1A1SMN1; SMN2POLB
SCHEMBL23331262 0.74 TP53 (0.40) HSD17B10KDM4EKMT2AALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230028221-A1 EED INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF JING MEDICINE TECHNOLOGY (SHANGHAI) LTD. (CN) 2023-01-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230028221-A1 EED INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF CYP4F11, CYP4A11, HSD11B1 HSD17B10 332/4885KDM4E 2018/4885KMT2A 3987/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback