Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 6/20 | 0.46 |
| ▸ | CKS1B | P61024 | 2/20 | 0.45 |
| ▸ | SKP1 | P63208 | 2/20 | 0.45 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30164198 | 1.00 | GPR119 (0.49) | GPR119NR1H2NR1H3KCNH2RET | |
| Hydrochloric Acid SCHEMBL30164036 | 0.93 | ALDH1A1 (0.45) | GPR119NR1H2NR1H3KCNH2RET | |
| SCHEMBL29232158 | 0.89 | GPR119 (0.46) | GPR119NR1H2NR1H3KCNH2RET | |
| SCHEMBL30163917 | 0.89 | GPR119 (0.46) | GPR119NR1H2NR1H3KCNH2RET | |
| Hydrochloric Acid SCHEMBL30164052 | 0.83 | GPR119 (0.42) | GPR119NR1H2NR1H3KCNH2RET | |
| SCHEMBL31651709 | 0.83 | TLR9 (0.49) | GPR119CKS1BSKP1SKP2GBA1 | |
| SCHEMBL30163998 | 0.81 | NR1H2 (0.45) | GPR119NR1H2NR1H3KCNH2RET | |
| SCHEMBL29232144 | 0.81 | NR1H2 (0.45) | GPR119NR1H2NR1H3KCNH2RET | |
| SCHEMBL4573148 | 0.80 | GRIA1 (0.49) | GPR119NR1H2NR1H3RETCKS1B | |
| SCHEMBL3538823 | 0.79 | KDM4E (0.59) | GPR119NR1H2NR1H3ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118159530-A | Compounds for the treatment of pain, in particular neuropathic pain and/or other diseases or disorders associated with AT2R and/or AT2R mediated signalling | 康福治疗有限公司 | 2024-06-07 | — | — | CN | disclosed |
| WO-2023006893-A1 | COMPOUNDS FOR THE TREATMENT OF PAIN, IN PARTICULAR NEUROPATHIC PAIN, AND/OR OTHER DISEASES OR DISORDERS THAT ARE ASSOCIATED WITH AT2R AND/OR AT2R MEDIATED SIGNALING | CONFO THERAPEUTICS N.V. (BE) | 2023-02-02 | — | — | WO | disclosed |