Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.46 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24986790 | 0.80 | GPR119 (0.49) | NR1H2NR1H3GPR119RETLMNA | |
| SCHEMBL30164198 | 0.80 | GPR119 (0.49) | NR1H2NR1H3GPR119RETLMNA | |
| SCHEMBL20159138 | 0.78 | GPR119 (0.48) | NR1H2NR1H3GPR119RETLMNA | |
| SCHEMBL3920960 | 0.78 | GRIA1 (0.48) | GRIA1NR1H2NR1H3LMNAMAPT | |
| SCHEMBL8154203 | 0.77 | PDE4A (0.49) | GRIA1LMNAMAPTMAPK1HTT | |
| SCHEMBL30163998 | 0.77 | NR1H2 (0.45) | NR1H2NR1H3GPR119RETLMNA | |
| SCHEMBL29232144 | 0.77 | NR1H2 (0.45) | NR1H2NR1H3GPR119RETLMNA | |
| SCHEMBL2459991 | 0.77 | GPR119 (0.50) | NR1H2NR1H3GPR119RETLMNA | |
| SCHEMBL29232158 | 0.76 | GPR119 (0.46) | NR1H2NR1H3GPR119RETLMNA | |
| SCHEMBL30163917 | 0.76 | GPR119 (0.46) | NR1H2NR1H3GPR119RETLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |