Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | G6PD | P11413 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20797607 | 0.88 | ALDH1A1 (0.49) | ALDH1A1TDP1LMNAMAPTL3MBTL1 | |
| SCHEMBL5157517 | 0.86 | ALDH1A1 (0.53) | ALDH1A1TDP1MAPTL3MBTL1HTR1A | |
| SCHEMBL20797772 | 0.85 | KMT2A (0.47) | ALDH1A1TDP1LMNAMAPTL3MBTL1 | |
| SCHEMBL14249377 | 0.84 | ALDH1A1 (0.57) | ALDH1A1TDP1LMNAMAPTL3MBTL1 | |
| SCHEMBL31700569 | 0.83 | LMNA (0.52) | ALDH1A1LMNAMAPTL3MBTL1HCAR3 | |
| SCHEMBL17243849 | 0.81 | LMNA (0.50) | ALDH1A1TDP1LMNAMAPTL3MBTL1 | |
| SCHEMBL13554669 | 0.81 | LMNA (0.50) | ALDH1A1TDP1LMNAMAPTL3MBTL1 | |
| SCHEMBL24853732 | 0.80 | ALDH1A1 (0.47) | ALDH1A1TDP1LMNAMAPTL3MBTL1 | |
| SCHEMBL29617958 | 0.80 | ALDH1A1 (0.47) | ALDH1A1TDP1LMNAMAPTL3MBTL1 | |
| SCHEMBL23273490 | 0.80 | MEN1 (0.52) | ALDH1A1LMNAMAPTL3MBTL1HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030497-B2 | Benzimidazole derivatives | NOVARTIS AG (CH) | 2011-10-04 | — | — | US | disclosed |
| US-8030497-B2 | Benzimidazole derivatives | NOVARTIS AG (CH) | 2011-10-04 | — | — | US | disclosed |
| US-20090170921-A1 | Benzimidazole derivatives | NOVARTIS AG (CH) | 2009-07-02 | — | — | US | disclosed |
| US-20090170921-A1 | Benzimidazole derivatives | NOVARTIS AG (CH) | 2009-07-02 | — | — | US | disclosed |
| EP-1709006-A1 | BENZIMIDAZOLE DERIVATIVES | Novartis AG (CH) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005068433-A9 | BENZIMIDAZOLE DERIVATIVES | NOVARTIS AG (CH) | 2005-09-15 | — | — | WO | disclosed |
| WO-2005068433-A1 | BENZIMIDAZOLE DERIVATIVES | NOVARTIS AG (CH) | 2005-07-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170921-A1 | Benzimidazole derivatives | CYP3A7, UGT2B7, CYP2B6 | ALDH1A1 208/4885TDP1 3197/4885LMNA 3162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.