SCHEMBL25002993

SCHEMBL25002993

Cc1cccc2c1CC(F)(F)C2=O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.45
ACHE P22303 1/20 0.43
PARP1 P09874 1/20 0.42
PARP10 Q53GL7 1/20 0.42
PARP11 Q9NR21 1/20 0.42
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA7 P43166 1/20 0.41
CA9 Q16790 1/20 0.41
LMNA P02545 2/20 0.39
KDM4E B2RXH2 1/20 0.38
DAO P14920 1/20 0.38
TYMS P04818 2/20 0.33
HTR2A P28223 1/20 0.33
HTR2C P28335 1/20 0.33
HTR2B P41595 1/20 0.33
MEN1 O00255 1/20 0.33
POLB P06746 1/20 0.33
KMT2A Q03164 1/20 0.33
DDB1 Q16531 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12261408 0.79 ALDH1A1 (0.50) ALDH1A1ACHEPARP1PARP10PARP11
SCHEMBL25003063 0.78 CDK5 (0.44) PARP10PARP11CA1CA2CA7
SCHEMBL18071522 0.77 ACHE (0.49) ALDH1A1ACHECA1CA2CA7
SCHEMBL27952596 0.76 ALDH1A1 (0.47) ALDH1A1ACHEPARP1PARP10PARP11
SCHEMBL15746305 0.75 ALDH1A1 (0.42) ALDH1A1ACHEPARP1PARP10PARP11
SCHEMBL29505991 0.73 PARP1 (0.45) ALDH1A1ACHEPARP1PARP10PARP11
SCHEMBL21856255 0.73 PARP1 (0.45) ALDH1A1ACHEPARP1PARP10PARP11
SCHEMBL7184848 0.73 ALDH1A1 (0.44) ALDH1A1ACHEPARP1PARP10PARP11
SCHEMBL14939135 0.71 ALDH1A1 (0.40) ALDH1A1ACHEPARP1PARP10PARP11
SCHEMBL12086607 0.71 ALDH1A1 (0.43) ALDH1A1ACHEPARP1PARP10PARP11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023011608-A1 REGULATOR CONTAINING TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 上海枢境生物科技有限公司 2023-02-09 WO disclosed