Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | HTR2B | P41595 | 3/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25005258 | 0.80 | KDM4E (0.38) | SLC6A4KDM4EKDM1AHTR2BHTR2A | |
| SCHEMBL30224671 | 0.75 | KDM4E (0.34) | SLC6A4KDM4EKDM1ACNR1CNR2 | |
| SCHEMBL24987024 | 0.72 | PARP1 (0.55) | KDM4EGRIN1NR1H2NR1H3PSMD14 | |
| SCHEMBL23993219 | 0.71 | CHRNB2 (0.39) | SLC6A4CHRNB2CHRNA4KDM1AHTR2C | |
| SCHEMBL3051052 | 0.71 | PSMD14 (0.41) | KDM4ECNR1CNR2NR1H2NR1H3 | |
| SCHEMBL25004716 | 0.70 | SLC6A4 (0.39) | SLC6A4CHRNB2CHRNA4KDM1AHTR2C | |
| SCHEMBL26563578 | 0.70 | PARP1 (0.43) | KDM4ENR1H2NR1H3PSMD14COPS5 | |
| SCHEMBL22326604 | 0.70 | PSMD14 (0.64) | KDM4ECNR1CNR2NR1H2NR1H3 | |
| SCHEMBL23993630 | 0.69 | HTR2C (0.70) | SLC6A4KDM1AHTR2CHTR2BHTR2A | |
| SCHEMBL15767914 | 0.69 | HTR2C (0.70) | SLC6A4KDM1AHTR2CHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230039553-A1 | CD73 COMPOUNDS | GILEAD SCIENCES, INC. | 2023-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230039553-A1 | CD73 COMPOUNDS | ENTPD5, ENTPD1, NT5E | SLC6A4 1120/4885CHRNB2 1900/4885CHRNA4 1552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.