Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19435586 | 0.91 | CLK4 (0.38) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL10731993 | 0.80 | MAPT (0.46) | KMT2AMEN1NOTUMNPC1RAB9A | |
| SCHEMBL4303322 | 0.80 | MEN1 (0.56) | KMT2AMEN1NPC1RAB9ACCNB2 | |
| SCHEMBL27668598 | 0.79 | CLK4 (0.66) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL11840271 | 0.79 | LMNA (0.42) | KMT2AMEN1NISCHALDH1A1NPC1 | |
| SCHEMBL17701519 | 0.79 | KIF11 (0.48) | KMT2ANISCHALDH1A1NPC1RAB9A | |
| SCHEMBL30186716 | 0.79 | NPC1 (0.52) | NOTUMALDH1A1NPC1RAB9APOLB | |
| SCHEMBL6484311 | 0.79 | NPC1 (0.52) | NOTUMALDH1A1NPC1RAB9APOLB | |
| SCHEMBL6181561 | 0.79 | MAPT (0.46) | KMT2AMEN1NOTUMNPC1RAB9A | |
| SCHEMBL14656056 | 0.79 | NPC1 (0.52) | NOTUMALDH1A1NPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370413-A1 | MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010077275-A1 | MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |