Ephedrine

Ephedrine

SCHEMBL2501430

CC(N)Cc1ccccc1.CN[C@@H](C)[C@H](O)c1ccccc1

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3

The experimentally established mechanism targets of Ephedrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA2C known ✓ P18825 2/20 0.69
ADRA1A known ✓ P35348 1/20 0.69
ADRA2A known ✓ P08913 1/20 0.49
CHRM2 P08172 1/20 0.69
RGS12 O14924 1/20 0.69
GLA P06280 1/20 0.69
CYP3A4 P08684 1/20 0.69
CYP2D6 P10635 1/20 0.69
CYP2C9 P11712 1/20 0.69
PKM P14618 1/20 0.69
ALOX15 P16050 1/20 0.69
TSHR P16473 1/20 0.69
ALOX12 P18054 1/20 0.69
NFKB1 P19838 1/20 0.69
HTR2A P28223 1/20 0.69
CYP2C19 P33261 1/20 0.69
THPO P40225 1/20 0.69
GNAI1 P63096 1/20 0.69
HSD17B10 Q99714 1/20 0.69
KMT2A Q03164 2/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ephedrine SCHEMBL16196643 0.86 ADRA1A (0.71) ADRA2CCHRM2ADRA1ARGS12GLA
Pseudoephedrine SCHEMBL16601218 0.86 ADRA1A (0.71) ADRA2CCHRM2ADRA1ARGS12GLA
Racephedrine SCHEMBL28739755 0.83 ADRA2C (0.92) ADRA2CCHRM2ADRA1ARGS12GLA
Ephedrine SCHEMBL4785 0.83 CYP2D6 (1.00) ADRA2CCHRM2ADRA1ARGS12GLA
Racephedrine SCHEMBL12573578 0.83 CYP2D6 (1.00) ADRA2CCHRM2ADRA1ARGS12GLA
Racephedrine SCHEMBL4786 0.83 CYP2D6 (1.00) ADRA2CCHRM2ADRA1ARGS12GLA
Racephedrine SCHEMBL11906521 0.83 CYP2D6 (1.00) ADRA2CCHRM2ADRA1ARGS12GLA
Ephedrine SCHEMBL4731265 0.83 CYP2D6 (1.00) ADRA2CCHRM2ADRA1ARGS12GLA
Pseudoephedrine SCHEMBL4368 0.83 CYP2D6 (1.00) ADRA2CCHRM2ADRA1ARGS12GLA
Racephedrine SCHEMBL4369 0.83 CYP2D6 (1.00) ADRA2CCHRM2ADRA1ARGS12GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115272711-A Device for detecting drugs by utilizing structural color of photonic crystal 公安部物证鉴定中心 2022-11-01 CN disclosed
CN-115272710-A Fast drug detection method, equipment and medium based on photonic crystal image 公安部物证鉴定中心 2022-11-01 CN disclosed
EP-1817008-B1 STABILIZED HME COMPOSITION WITH SMALL DRUG PARTICLES UNIV TEXAS (US) 2020-04-01 EP disclosed
EP-3368084-A1 PHARMACEUTICAL COMPOSITIONS FOR TRANSMUCOSAL DELIVERY Solubest Ltd (IL) 2018-09-05 EP disclosed
US-9867786-B2 Stabilized compositions containing alkaline labile drugs AUXILIUM US HOLDINGS, LLC (US) 2018-01-16 US disclosed
US-9730894-B2 Stabilized HME composition with small drug particles BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2017-08-15 US disclosed
US-20170119660-A1 PHARMACEUTICAL COMPOSITIONS FOR TRANSMUCOSAL DELIVERY SOLUBEST LTD (IL) 2017-05-04 US disclosed
WO-2017072774-A1 PHARMACEUTICAL COMPOSITIONS FOR TRANSMUCOSAL DELIVERY SOLUBEST LTD (IL) 2017-05-04 WO disclosed
US-20170119669-A1 STABILIZED HME COMPOSITION WITH SMALL DRUG PARTICLES UNIV TEXAS (US) 2017-05-04 US disclosed
EP-2010366-B1 PROCESS FOR THE PREPARATION OF A HOT-MELT EXTRUDED LAMINATE AUXILIUM INT HOLDINGS INC (US) 2017-03-22 EP disclosed
EP-1248598-A4 OSMOTIC DEVICE HAVING A PREFORMED PASSAGEWAY THAT INCREASES IN SIZE OSMOTICA CORP (VG) 2004-01-21 EP disclosed
EP-0914098-B1 MULTI-LAYERED OSMOTIC DEVICE OSMOTICA CORP (VG) 2003-10-01 EP disclosed
US-6599284-B2 Osmotic device having a preformed passageway that increases in size OSMOTICA CORP. (VG) 2003-07-29 US disclosed
EP-1248598-A1 OSMOTIC DEVICE HAVING A PREFORMED PASSAGEWAY THAT INCREASES IN SIZE Osmotica Corp. (VG) 2002-10-16 EP disclosed
US-20020099361-A1 Osmotic device having a preformed passageway that increases in size CIBC BANK USA, AS ADMINISTRATIVE AGENT 2002-07-25 US disclosed
EP-0914098-A4 MULTI-LAYERED OSMOTIC DEVICE PHOENIX U S A INC LAB (US) 2001-12-19 EP disclosed
WO-2001052819-A1 OSMOTIC DEVICE HAVING A PREFORMED PASSAGEWAY THAT INCREASES IN SIZE OSMOTICA CORP. (VG) 2001-07-26 WO disclosed
US-6004582-A FOR IMMEDIATE DELIVERY OF A FIRST ACTIVE AGENT FOLLOWED BY A MONITORED, CONTINUOUS, CONTROLLED AND/OR RETARDED DELIVERY OF A SECOND ACTIVE AGENT WHICH IS THE SAME OR DIFFERENT AS THE FIRST ACTIVE AGENT; TIME-RELEASE AGENTS LABORATORIOS PHOENIX U.S.A, INC. (AR) 1999-12-21 US disclosed
EP-0914098-A1 MULTI-LAYERED OSMOTIC DEVICE Laboratorios Phoenix U.S.A., Inc. (US) 1999-05-12 EP disclosed
WO-1998053802-A1 MULTI-LAYERED OSMOTIC DEVICE LABORATORIOS PHOENIX U.S.A., INC. (US) 1998-12-03 WO disclosed