Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 5/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 5/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25015749 | 0.86 | F2 (0.45) | F10F2PRSS1HTR7CNR2 | |
| SCHEMBL25016234 | 0.84 | HSD11B1 (0.38) | F10HSD11B1HSD17B1F2PRSS1 | |
| SCHEMBL25016289 | 0.83 | F10 (0.39) | F10F2PRSS1 | |
| SCHEMBL25016269 | 0.82 | NPC1 (0.43) | F10F2PRSS1CNR2NPC1 | |
| SCHEMBL25015870 | 0.80 | ST14 (0.48) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL25017307 | 0.79 | F10 (0.49) | F10F2PRSS1NPC1POLB | |
| SCHEMBL25015867 | 0.79 | ITGB3 (0.36) | F10F2PRSS1ITGB3ITGA2B | |
| SCHEMBL25016298 | 0.77 | NAMPT (0.35) | F10F2PRSS1ITGB3ITGA2B | |
| SCHEMBL25016737 | 0.76 | PRSS1 (0.45) | F10F2PRSS1ITGB3ITGA2B | |
| SCHEMBL25016759 | 0.76 | F2 (0.42) | F10F2PRSS1CNR2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230043159-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | DISC MEDICINE, INC. | 2023-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230043159-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | MMP7, MATR3, SPINT2 | F10 1548/4885HSD11B1 2151/4885HSD17B1 2092/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.