Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 1/20 | 0.45 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 2/20 | 0.35 |
| ▸ | CTRC | Q99895 | 1/20 | 0.34 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 2/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | TEK | Q02763 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19102829 | 0.74 | CALM1 (0.55) | SORT1CALM1DAOBCL2BCL2L1 | |
| SCHEMBL6513885 | 0.64 | CALM1 (0.42) | SORT1CALM1MAOAMAOBDAO | |
| SCHEMBL23189253 | 0.63 | PLA2G2A (0.49) | SORT1CALM1MEN1USP2MAPT | |
| SCHEMBL5236829 | 0.63 | SORT1 (0.47) | SORT1CALM1MAOAMAOBDAO | |
| SCHEMBL1923108 | 0.62 | CALM1 (0.58) | CALM1DAOBCL2BCL2L1IDH1 | |
| SCHEMBL8414683 | 0.62 | CALM1 (0.39) | SORT1CALM1MAOAMAOBDAO | |
| SCHEMBL11963994 | 0.62 | SORT1 (1.00) | SORT1CALM1MAOAMAOBDAO | |
| SCHEMBL4866616 | 0.62 | CALM1 (0.44) | SORT1CALM1MAOAMAOBDAO | |
| SCHEMBL981029 | 0.60 | CALM1 (0.42) | SORT1CALM1MAOAMAOBDAO | |
| Diphenylmethane SCHEMBL1303 | 0.60 | CALM1 (1.00) | CALM1MAOBBCL2BCL2L1IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104163799-A | Preparing method of 3-amino-4-isoquinolinecarbonitrile-1(2H)-one derivatives | UNIV SOOCHOW | 2014-11-26 | — | — | CN | claimed |
| CN-1787999-A | Histone deacetylase inhibitors | TAKEDA SAN DIEGO INC (US) | 2006-06-14 | — | — | CN | claimed |
| EP-3921327-A1 | GLYCYRRHETINIC ACID DERIVATIVES FOR USE IN TREATING HYPERKALEMIA | Ardelyx, Inc. (US) | 2021-12-15 | — | — | EP | disclosed |
| WO-2020163642-A1 | GLYCYRRHETINIC ACID DERIVATIVES FOR USE IN TREATING HYPERKALEMIA | ARDELYX, INC. (US) | 2020-08-13 | — | — | WO | disclosed |
| CN-104163799-B | 3-amino-4-Cyanoisoquinoline-1(2H) preparation method of-one derivant | 苏州大学 | 2016-08-17 | — | — | CN | disclosed |
| CN-104163799-A | Preparing method of 3-amino-4-isoquinolinecarbonitrile-1(2H)-one derivatives | UNIV SOOCHOW | 2014-11-26 | — | — | CN | disclosed |
| US-8030499-B2 | 1,3-dihydro-2H-indole-2-one compound and pyrrolidine-2-one compound fused with aromatic heterocycle | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-10-04 | — | — | US | disclosed |
| US-20080318923-A1 | 1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2008-12-25 | — | — | US | disclosed |
| US-20080132562-A1 | TETRONIC AND TETRAMIC ACIDS | GODEL THIERRY | 2008-06-05 | — | — | US | disclosed |
| CN-1972920-A | Arylalkyl piperazine derivatives for the treatment of conditions ameliorated by monoamine reuptake including vasomotor symptoms | WYETH CORP (US) | 2007-05-30 | — | — | CN | disclosed |
| CN-1065874-C | Novel peptides, the preparation and use thereof | BASF AG (DE) | 2001-05-16 | — | — | CN | disclosed |
| CN-1112125-A | Acyloxyhexanoic acid derivatives | CIBA GEIGY AG (CH) | 1995-11-22 | — | — | CN | disclosed |
| CN-1028143-C | Oxazolidinone sterilization composition | DU PONT (US) | 1995-04-12 | — | — | CN | disclosed |
| CN-1096157-A | Antifungal De oxazolidone | DU PONT (US) | 1994-12-14 | — | — | CN | disclosed |
| CN-1095724-A | New peptides, its preparation and application | BASF AG (DE) | 1994-11-30 | — | — | CN | disclosed |
| CN-1085563-A | New peptide and preparation thereof and application | BASF AG (DE) | 1994-04-20 | — | — | CN | disclosed |
| CN-1047079-A | FUNGICIDAL OXAZOLIDINONES | DU PONT (US) | 1990-11-21 | — | — | CN | disclosed |
| EP-0384271-A2 | Method for enhancement of chemiluminescence | WAKO PURE CHEMICAL INDUSTRIES LTD (JP) | 1990-08-29 | — | — | EP | disclosed |
| CN-1041942-A | Pyridine derivate | ICI PLC (GB) | 1990-05-09 | — | — | CN | disclosed |
| EP-0322800-A1 | Process for preparation of sulfone derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1989-07-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132562-A1 | TETRONIC AND TETRAMIC ACIDS | BACE1, PSEN1, BACE2 | SORT1 336/4885CALM1 667/4885MAOA 1077/4885 |
| US-20080318923-A1 | 1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle | AVPR1B, AVPR1A, AVPR2 | SORT1 3294/4885CALM1 2179/4885MAOA 637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.