Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 2/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.33 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | EBP | Q15125 | 1/20 | 0.33 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25856130 | 0.90 | ACHE (0.46) | ACHEPOLBKDM4EGBA1GNAO1 | |
| SCHEMBL13661595 | 0.89 | ACHE (0.64) | ACHEGBA1GNAO1CACNA2D1CACNA1B | |
| Hydrochloric Acid SCHEMBL22033207 | 0.88 | ACHE (0.62) | ACHEGBA1GNAO1CACNA2D1CACNA1B | |
| SCHEMBL13247999 | 0.88 | ACHE (0.62) | ACHEPOLBKDM4EOPRM1OPRL1 | |
| SCHEMBL29317185 | 0.87 | ACHE (0.44) | ACHEPOLBKDM4EGBA1GNAO1 | |
| SCHEMBL29317239 | 0.85 | ACHE (0.41) | ACHEPOLBKDM4EGBA1CACNA2D1 | |
| SCHEMBL24480218 | 0.85 | ACHE (0.50) | ACHEPOLBKDM4EOPRM1OPRL1 | |
| SCHEMBL24196541 | 0.83 | CHRM5 (0.48) | ACHEKDM4EGBA1CACNA2D1CACNA1B | |
| SCHEMBL25027108 | 0.82 | ACHE (0.38) | ACHEPOLBKDM4EGBA1 | |
| SCHEMBL25856386 | 0.82 | ACHE (0.38) | ACHEGBA1GNAO1CACNA2D1CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4397661-A1 | COMPOUND FOR DEGRADATION OF BCL-2 FAMILY PROTEINS AND MEDICAL APPLICATION THEREOF | Xizang Haisco Pharmaceutical Co., Ltd. (CN) | 2024-07-10 | — | — | EP | disclosed |
| WO-2023016518-A1 | HETEROCYCLIC DERIVATIVE, AND COMPOSITION AND PHARMACEUTICAL USE THEREOF | 四川海思科制药有限公司 | 2023-02-16 | — | — | WO | disclosed |