Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2B | Q02880 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25032061 | 0.89 | PDE5A (0.43) | TOP2BSMN1; SMN2MAPTKMT2ALRRK2 | |
| SCHEMBL25033617 | 0.85 | PTGS2 (0.42) | TOP2BSMN1; SMN2KMT2ALRRK2PTGS2 | |
| SCHEMBL25032057 | 0.82 | MAPT (0.38) | TOP2BSMN1; SMN2MAPTKMT2AALDH1A1 | |
| SCHEMBL25032067 | 0.81 | KMT2A (0.40) | SMN1; SMN2MAPTKMT2AALDH1A1LMNA | |
| SCHEMBL25032074 | 0.81 | KMT2A (0.40) | SMN1; SMN2MAPTKMT2ALRRK2PTGS2 | |
| SCHEMBL23144748 | 0.79 | TOP2B (0.48) | TOP2BSMN1; SMN2LRRK2IRAK4ALDH1A1 | |
| SCHEMBL29397321 | 0.79 | TTK (0.46) | TOP2BLRRK2PTGS2MAPK1PDE5A | |
| SCHEMBL25033642 | 0.79 | RORC (0.39) | SMN1; SMN2MAPTKMT2ALRRK2ALDH1A1 | |
| SCHEMBL24035187 | 0.78 | TOP2B (0.50) | TOP2BSMN1; SMN2MAPTLRRK2IRAK4 | |
| SCHEMBL30295655 | 0.78 | TOP2B (0.50) | TOP2BSMN1; SMN2MAPTLRRK2IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023016434-A1 | COMPOUNDS TARGETING MUTANT OF P53 | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2023-02-16 | — | — | WO | disclosed |