Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA3 | P32297 | 15/20 | 1.00 |
| ▸ | CHRNB2 | P17787 | 14/20 | 1.00 |
| ▸ | CHRNB4 | P30926 | 8/20 | 0.73 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.66 |
| ▸ | CHRNB1 | P11230 | 3/20 | 0.65 |
| ▸ | CHRNB3 | Q05901 | 3/20 | 0.65 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14303749 | 1.00 | CHRNA3 (1.00) | CHRNA3CHRNB2CHRNB4CHRNA2CHRNB1 | |
| SCHEMBL2499415 | 0.99 | CHRNA3 (1.00) | CHRNA3CHRNB2CHRNB4CHRNA2CHRNB1 | |
| Hydrochloric Acid SCHEMBL6581830 | 0.98 | CHRNA3 (0.98) | CHRNA3CHRNB2CHRNB4CHRNA2CHRNB1 | |
| SCHEMBL7672186 | 0.91 | CHRNB2 (0.92) | CHRNA3CHRNB2CHRNB4CHRNA2CHRNB1 | |
| SCHEMBL6584638 | 0.91 | CHRNB2 (0.92) | CHRNA3CHRNB2CHRNB4CHRNA2CHRNB1 | |
| SCHEMBL6584306 | 0.91 | CHRNB2 (0.92) | CHRNA3CHRNB2CHRNB4CHRNA2CHRNB1 | |
| Hydrochloric Acid SCHEMBL6586011 | 0.90 | CHRNB2 (0.90) | CHRNA3CHRNB2CHRNB4CHRNA2CHRNB1 | |
| Hydrochloric Acid SCHEMBL6581802 | 0.90 | CHRNB2 (0.90) | CHRNA3CHRNB2CHRNB4CHRNA2CHRNB1 | |
| Hydrochloric Acid SCHEMBL6583181 | 0.90 | CHRNB2 (0.90) | CHRNA3CHRNB2CHRNB4CHRNA2CHRNB1 | |
| SCHEMBL13322058 | 0.90 | CHRNB2 (0.94) | CHRNA3CHRNB2CHRNB4CHRNA2CHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8642612-B2 | Nicotinic desensitizers and methods of selecting, testing, and using them | POTOMAC PHARMACEUTICALS, INC. (US) | 2014-02-04 | — | — | US | disclosed |
| US-8642612-B2 | Nicotinic desensitizers and methods of selecting, testing, and using them | POTOMAC PHARMACEUTICALS, INC. (US) | 2014-02-04 | — | — | US | disclosed |
| US-8030300-B2 | 2-pyrrolidinyloxy-substituted pyridine; Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder | GEORGETOWN UNIVERSITY (US) | 2011-10-04 | — | — | US | disclosed |
| US-20100129291-A1 | NICOTINIC DESENSITIZERS AND METHODS OF SELECTING, TESTING, AND USING THEM | BETHESDA PHARMACOLOGY ASSOCIATES (US) | 2010-05-27 | — | — | US | disclosed |
| US-20080132486-A1 | Ligands for Nicotinic Acetylcholine Receptors, and Methods of Making and Using Them | GEORGETOWN UNIVERSITY (US) | 2008-06-05 | — | — | US | disclosed |
| WO-2008011484-A2 | NICOTINIC DESENSITIZERS AND METHODS OF SELECTING, TESTING, AND USING THEM | BETHESDA PHARMACOLOGY ASSOCIATES, LLC (US) | 2008-01-24 | — | — | WO | disclosed |
| WO-2005000806-A2 | LIGANDS FOR NICOTINIC ACETYLCHOLINE RECEPTORS, AND METHODS OF MAKING AND USING THEM | GEORGETOWN UNIVERSITY (US) | 2005-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132486-A1 | Ligands for Nicotinic Acetylcholine Receptors, and Methods of Making and Using Them | CHRNA5, OPRL1, TAAR5 | CHRNA3 20/4885CHRNB2 36/4885CHRNB4 26/4885 |
| US-20100129291-A1 | NICOTINIC DESENSITIZERS AND METHODS OF SELECTING, TESTING, AND USING THEM | CHRNA5, CHRNA2, CHRNA10 | CHRNA3 10/4885CHRNB2 7/4885CHRNB4 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.