Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 14/20 | 0.44 |
| ▸ | MERTK | Q12866 | 8/20 | 0.44 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 6/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29155030 | 0.94 | LMNA (0.40) | AXLMERTKRIPK3METDGAT1 | |
| SCHEMBL21185525 | 0.92 | AXL (0.47) | AXLMERTK | |
| SCHEMBL25037802 | 0.86 | AXL (0.43) | AXLMERTKRIPK3MET | |
| SCHEMBL21176856 | 0.84 | IRAK4 (0.43) | AXLMETDGAT1SOAT1NPC1 | |
| SCHEMBL21185436 | 0.80 | PKM (0.44) | AXLMERTKNPC1RAB9AGABRA2 | |
| SCHEMBL20351471 | 0.80 | AXL (0.54) | AXLMERTKMET | |
| SCHEMBL25035781 | 0.80 | SCD (0.40) | AXLMERTKMET | |
| SCHEMBL25037951 | 0.80 | LMNA (0.46) | NPC1LMNARAB9AGABRA2GABRB2 | |
| SCHEMBL21185430 | 0.80 | AXL (0.45) | AXLMERTK | |
| SCHEMBL30499536 | 0.79 | LMNA (0.51) | NPC1LMNARAB9AGABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117561260-A | Heterocyclic compound, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2024-02-13 | — | — | CN | disclosed |
| WO-2023016296-A1 | HETEROCYCLIC COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2023-02-16 | — | — | WO | disclosed |