Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 9/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26942730 | 0.92 | PPARD (0.36) | PPARDMAPTPDE2ATHRBSLC6A3 | |
| SCHEMBL24394026 | 0.90 | PPARD (0.36) | PPARDMAPTPDE2ATHRBSLC6A3 | |
| SCHEMBL25042483 | 0.89 | THRB (0.37) | PDE2ATHRBSLC6A3SLC6A4EPHX2 | |
| SCHEMBL24393983 | 0.88 | PPARD (0.37) | PPARDMAPTTHRBALDH1A1SLC6A3 | |
| SCHEMBL25043526 | 0.87 | LMNA (0.32) | MAPTTHRBALDH1A1SLC6A3SLC6A4 | |
| SCHEMBL25043354 | 0.86 | SLC6A3 (0.38) | PDE2ATHRBSLC6A3SLC6A4 | |
| SCHEMBL24393987 | 0.84 | EPHX2 (0.36) | PPARDMAPTPDE2ATHRBALDH1A1 | |
| SCHEMBL25043532 | 0.83 | SLC6A3 (0.38) | PDE2ATHRBALDH1A1SLC6A3SLC6A4 | |
| SCHEMBL24803200 | 0.82 | SLC6A3 (0.38) | MAPTPDE2ATHRBSLC6A3SLC6A4 | |
| SCHEMBL24394104 | 0.82 | THRB (0.37) | PDE2ATHRBSLC6A3SLC6A4EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4384271-A1 | DERIVATIVES OF ITACONIC ACID AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | Sitryx Therapeutics Limited (GB) | 2024-06-19 | — | — | EP | disclosed |
| WO-2023017269-A1 | DERIVATIVES OF ITACONIC ACID AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | SITRYX THERAPEUTICS LIMITED (GB) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023017269-A1 | DERIVATIVES OF ITACONIC ACID AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | SITRYX THERAPEUTICS LIMITED (GB) | 2023-02-16 | — | — | WO | disclosed |