Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 10/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 7/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20313343 | 0.90 | KDM4E (0.42) | KDM4ENPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL20316320 | 0.81 | KDM4E (0.42) | KDM4ENPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL20312710 | 0.80 | KEAP1 (0.46) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL23634123 | 0.79 | CA1 (0.38) | KDM4EMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL18322537 | 0.76 | KEAP1 (0.47) | KDM4ENPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL31697556 | 0.76 | KEAP1 (0.47) | KDM4ENPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL9524820 | 0.75 | KEAP1 (0.52) | KDM4ENPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL24650615 | 0.75 | KEAP1 (0.38) | KDM4ENPC1RAB9ASMN1; SMN2KEAP1 | |
| SCHEMBL29490008 | 0.75 | KEAP1 (0.38) | KDM4ENPC1RAB9ASMN1; SMN2KEAP1 | |
| SCHEMBL16406906 | 0.74 | APP (0.49) | KDM4ENPC1ALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230047296-A1 | Nrf2 REGULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230047296-A1 | Nrf2 REGULATORS | NFE2L2, KEAP1, NQO1 | KDM4E 1750/4885NPC1 316/4885ALDH1A1 621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.