Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30184710 | 1.00 | TRPV4 (0.62) | TRPV4ALDH1A1SMN1; SMN2POLBTSHR | |
| SCHEMBL10641518 | 0.86 | ALDH1A1 (0.57) | TRPV4ALDH1A1SMN1; SMN2POLBTSHR | |
| SCHEMBL13450384 | 0.84 | ALDH1A1 (0.48) | TRPV4ALDH1A1SMN1; SMN2POLBTSHR | |
| SCHEMBL16308958 | 0.83 | ALDH1A1 (0.47) | TRPV4ALDH1A1SMN1; SMN2POLBTSHR | |
| SCHEMBL30392211 | 0.83 | CA1 (0.50) | TRPV4ALDH1A1SMN1; SMN2POLBTSHR | |
| SCHEMBL23598878 | 0.83 | CA1 (0.50) | TRPV4ALDH1A1SMN1; SMN2POLBTSHR | |
| SCHEMBL16259602 | 0.78 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2POLBTSHRHDAC4 | |
| SCHEMBL2947794 | 0.77 | TRPV4 (1.00) | TRPV4ALDH1A1POLBTSHRHPGD | |
| SCHEMBL74997 | 0.77 | TRPV4 (0.68) | TRPV4ALDH1A1CA1CA2 | |
| SCHEMBL533956 | 0.77 | TRPV4 (0.68) | TRPV4ALDH1A1SMN1; SMN2POLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023016484-A1 | SULFONAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 江苏恒瑞医药股份有限公司 | 2023-02-16 | — | — | WO | disclosed |