Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | P4HA1 | P13674 | 2/20 | 0.37 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | TPMT | P51580 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12763742 | 0.82 | HCAR2 (0.43) | HCAR2NAPRTTTRTSHRMGAM | |
| SCHEMBL25047555 | 0.80 | MAPK1 (0.46) | MAPK1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL22748276 | 0.79 | HCAR2 (0.43) | HCAR2MGAMP4HA1P4HTMTPMT | |
| Hydrochloric Acid SCHEMBL3650688 | 0.78 | HCAR2 (0.40) | HCAR2NAPRTTTRTSHRMGAM | |
| SCHEMBL8341810 | 0.76 | HCAR2 (0.47) | HCAR2NAPRTTTRTSHRMGAM | |
| SCHEMBL232290 | 0.75 | HCAR2 (0.50) | HCAR2NAPRTTTRTSHRMGAM | |
| SCHEMBL29365646 | 0.75 | HCAR2 (0.50) | HCAR2NAPRTTTRTSHRMGAM | |
| SCHEMBL21407545 | 0.75 | MRGPRX4 (0.40) | HCAR2NAPRTTTRTSHRMGAM | |
| Hydrochloric Acid SCHEMBL7476482 | 0.73 | HCAR2 (0.48) | HCAR2NAPRTTTRTSHRMGAM | |
| SCHEMBL3650453 | 0.73 | HCAR2 (0.48) | HCAR2NAPRTTTRTSHRMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117460722-A | Nicotinamide RIPK1 inhibitors | 艾伯维公司 | 2024-01-26 | — | — | CN | disclosed |
| US-11767310-B2 | Nicotinamide RIPK1 inhibitors | ABBVIE INC. (US) | 2023-09-26 | — | — | US | disclosed |
| US-11767310-B2 | Nicotinamide RIPK1 inhibitors | ABBVIE INC. (US) | 2023-09-26 | — | — | US | disclosed |
| US-20230127127-A1 | NICOTINAMIDE RIPK1 INHIBITORS | ABBVIE INC. | 2023-04-27 | — | — | US | disclosed |
| US-20230127127-A1 | NICOTINAMIDE RIPK1 INHIBITORS | ABBVIE INC. | 2023-04-27 | — | — | US | disclosed |
| WO-2023018643-A1 | NICOTINAMIDE RIPK1 INHIBITORS | ABBVIE INC. (US) | 2023-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230127127-A1 | NICOTINAMIDE RIPK1 INHIBITORS | RIPK1, RIPK2, RIPK4 | HCAR2 464/4885NAPRT 42/4885TTR 4653/4885 |
| US-11767310-B2 | Nicotinamide RIPK1 inhibitors | RIPK1, RIPK2, RIPK4 | HCAR2 464/4885NAPRT 42/4885TTR 4653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.