Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.40 |
| ▸ | NCF1 | P14598 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.39 |
| ▸ | HTR3A | P46098 | 4/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.38 |
| ▸ | HTR3B | O95264 | 2/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL113927 | 0.84 | ADRB2 (0.55) | HTR6ADRB2NCF1ADRB1HTR3A | |
| SCHEMBL17675 | 0.78 | ADRB1 (0.51) | ADRB2NCF1ADRB1HTR3AHTR3E | |
| SCHEMBL16164 | 0.77 | MAPT (0.46) | ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL16844 | 0.77 | ADRB1 (0.50) | ADRB2NCF1ADRB1HTR3AHTR3E | |
| SCHEMBL7821730 | 0.72 | HTR6 (0.51) | HTR6HTR3AHTR2CHTR1DHTR1A | |
| SCHEMBL8707862 | 0.72 | HTR6 (0.54) | HTR6NCF1ADRB1HTR3AHTR3E | |
| SCHEMBL3919469 | 0.72 | ADRB2 (0.55) | HTR6ADRB2NCF1ADRB1HTR3A | |
| Hydrochloric Acid SCHEMBL5987357 | 0.71 | HTR6 (0.50) | HTR6HTR3AHTR2CALDH1A1HTR1D | |
| SCHEMBL24746308 | 0.71 | HSD11B1 (0.44) | — | |
| SCHEMBL20934590 | 0.71 | HSD11B1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609081-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | Amgen Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |