Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 8/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.43 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30833716 | 0.84 | IGF1R (0.52) | IGF1RKMT2AMEN1ALKCDK19 | |
| SCHEMBL4025891 | 0.84 | IGF1R (0.52) | IGF1RKMT2AMEN1ALKCDK19 | |
| SCHEMBL25056242 | 0.80 | IGF1R (0.48) | IGF1RKMT2AMEN1ALKCDK19 | |
| SCHEMBL600898 | 0.78 | GLO1 (0.51) | IGF1RKMT2AMEN1ALKCDK19 | |
| SCHEMBL30833802 | 0.78 | IGF1R (0.55) | IGF1RKMT2AMEN1ALKCDK19 | |
| SCHEMBL24260666 | 0.78 | IGF1R (0.55) | IGF1RKMT2AMEN1ALKCDK19 | |
| SCHEMBL17544687 | 0.78 | IGF1R (0.55) | IGF1RKMT2AMEN1ALKCDK19 | |
| SCHEMBL25056307 | 0.78 | MEN1 (0.52) | IGF1RKMT2AMEN1ALKCDK19 | |
| SCHEMBL21557746 | 0.78 | IGF1R (0.51) | IGF1RKMT2AMEN1ALKCDK19 | |
| SCHEMBL2843128 | 0.78 | ALK (0.58) | IGF1RKMT2AMEN1ALKCDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4137484-A1 | TRICYCLIC COMPOUNDS AS EGFR INHIBITORS | QILU PHARMACEUTICAL CO., LTD. (CN) | 2023-02-22 | — | — | EP | disclosed |