Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.54 |
| ▸ | BTK | Q06187 | 1/20 | 0.52 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.50 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7573051 | 0.83 | ADORA2A (0.55) | ADORA2AADORA1BTKPDCD1CD274 | |
| SCHEMBL19018356 | 0.80 | ADORA1 (0.47) | ADORA2AADORA1CD274ADORA2BHPGD | |
| SCHEMBL621540 | 0.79 | ADORA1 (0.56) | ADORA2AADORA1BTKPDCD1CD274 | |
| SCHEMBL5098820 | 0.79 | ADORA2A (0.47) | ADORA2AADORA1BTKTP53HPGD | |
| SCHEMBL7091942 | 0.75 | NPC1 (0.45) | ADORA2AADORA1ADORA2BHTTKDM4E | |
| SCHEMBL9469502 | 0.74 | ALDH1A1 (0.57) | ADORA2AADORA1ADORA2BTP53HPGD | |
| SCHEMBL2020140 | 0.72 | ABL1 (0.59) | ADORA2AADORA1TP53ALDH1A1GAA | |
| SCHEMBL952649 | 0.72 | HTR7 (0.49) | ADORA2AADORA1PDCD1CD274GRM2 | |
| SCHEMBL19731928 | 0.71 | CD274 (0.63) | ADORA1PDCD1CD274HTTKDM4E | |
| SCHEMBL9905199 | 0.71 | ALDH1A1 (0.49) | ADORA2AADORA1BTKTP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4137489-A1 | HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS | Incyte Corporation (US) | 2023-02-22 | — | — | EP | disclosed |