Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18883293 | 1.00 | NCF1 (0.39) | NCF1CYP1A2CYP2D6GBA1CNR1 | |
| SCHEMBL23874494 | 0.96 | ACHE (0.40) | NCF1CYP1A2CYP2D6GBA1CNR1 | |
| SCHEMBL21094260 | 0.94 | RAD52 (0.38) | NCF1CYP1A2CYP2D6GBA1CNR1 | |
| SCHEMBL945557 | 0.90 | NCF1 (0.45) | NCF1GBA1CNR1RAD52GNAO1 | |
| SCHEMBL2957778 | 0.89 | CHRM5 (0.41) | CYP2D6GBA1CNR1RAD52GNAO1 | |
| SCHEMBL151422 | 0.89 | CHRM5 (0.41) | CYP2D6GBA1CNR1RAD52GNAO1 | |
| SCHEMBL24480857 | 0.89 | ACHE (0.40) | NCF1GBA1CNR1RAD52GNAO1 | |
| SCHEMBL25026639 | 0.88 | NCF1 (0.43) | NCF1GBA1RAD52GNAO1POLB | |
| SCHEMBL19782068 | 0.88 | POLB (0.38) | GBA1CNR1RAD52GNAO1POLB | |
| SCHEMBL25026644 | 0.85 | GNAO1 (0.49) | NCF1CYP1A2CYP2D6GBA1GNAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023083194-A1 | WEE1 PROTEIN KINASE DEGRADATION AGENT AND USE THEREOF | 杭州格博生物医药有限公司 | 2023-05-19 | — | — | WO | disclosed |
| WO-2023023255-A1 | BIFUNCTIONAL DEGRADERS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND THERAPEUTIC USE THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-02-23 | — | — | WO | disclosed |