SCHEMBL19782068

SCHEMBL19782068

CN1CC(CN2CCNCC2)C1

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
CXCR4 P61073 2/20 0.36
RAD52 P43351 1/20 0.35
SIGMAR1 Q99720 3/20 0.34
HSD17B10 Q99714 1/20 0.33
CNR1 P21554 1/20 0.33
GBA1 P04062 1/20 0.33
ACHE P22303 1/20 0.32
CHRM5 P08912 2/20 0.32
ADRA2C P18825 1/20 0.32
ALDH1A1 P00352 1/20 0.32
GNAO1 P09471 1/20 0.32
CHRM3 P20309 1/20 0.32
KCNJ1 P48048 1/20 0.31
KCNH2 Q12809 1/20 0.31
LMNA P02545 1/20 0.31
PHGDH O43175 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24480857 0.92 ACHE (0.40) POLBSMN1; SMN2CXCR4RAD52SIGMAR1
SCHEMBL25074009 0.88 NCF1 (0.39) POLBSMN1; SMN2CXCR4RAD52SIGMAR1
SCHEMBL18883293 0.88 NCF1 (0.39) POLBSMN1; SMN2CXCR4RAD52SIGMAR1
SCHEMBL151422 0.84 CHRM5 (0.41) POLBSMN1; SMN2CXCR4RAD52SIGMAR1
SCHEMBL2957778 0.84 CHRM5 (0.41) POLBSMN1; SMN2CXCR4RAD52SIGMAR1
SCHEMBL23874494 0.84 ACHE (0.40) POLBSMN1; SMN2CXCR4RAD52SIGMAR1
SCHEMBL25568899 0.84 POLB (0.33) POLBSMN1; SMN2CXCR4RAD52SIGMAR1
SCHEMBL25815386 0.84 SMN1; SMN2 (0.34) POLBSMN1; SMN2GBA1ACHEGNAO1
SCHEMBL26705159 0.84 CHRM5 (0.39) SIGMAR1ACHECHRM5ADRA2CKCNH2
SCHEMBL24480215 0.83 GNAI3 (0.50) GBA1ACHECHRM5ADRA2CGNAO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023083194-A1 WEE1 PROTEIN KINASE DEGRADATION AGENT AND USE THEREOF 杭州格博生物医药有限公司 2023-05-19 WO disclosed
WO-2023004163-A1 BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK WITH ENHANCED IMID ACTIVITY NURIX THERAPEUTICS, INC. (US) 2023-01-26 WO disclosed
WO-2023287928-A1 BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK WITH DIMINISHED IMID ACTIVITY NURIX THERAPEUTICS, INC. (US) 2023-01-19 WO disclosed
WO-2022047145-A1 RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. (US) 2022-03-03 WO disclosed
WO-2021129653-A1 PROTEIN DEGRADATION AGENT COMPOUND PREPARATION METHOD AND APPLICATION 上海济煜医药科技有限公司 2021-07-01 WO disclosed
WO-2018013676-A1 SOMATOSTATIN MODULATORS AND USES THEREOF Crinetics Pharmaceuticals, Inc. (US) 2018-01-18 WO disclosed