SCHEMBL25077274

C=N[C@]1(COP(=O)(O)OC[C@@H](COCCCCCCCCCCCCCCCCCC)OCC2CCCCC2)O[C@@H](c2ccc3c(N)ncnn23)[C@H](O)[C@@H]1O

nearest known ligand 0.50

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	POLRMT	O00411	1/20	0.50

▸	MAPK14	Q16539	2/20	0.38

▸	AKT1	P31749	5/20	0.32

▸	AKT2	P31751	4/20	0.32

▸	AKT3	Q9Y243	4/20	0.32

▸	PIK3R1	P27986	3/20	0.32

▸	PIK3CA	P42336	3/20	0.32

▸	PLCG2	P16885	1/20	0.32

▸	GAB1	Q13480	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL25077226	0.91	POLRMT (0.44)	POLRMTMAPK14AKT1AKT2AKT3
SCHEMBL25077280	0.89	POLRMT (0.51)	POLRMTAKT1AKT2AKT3PIK3R1
SCHEMBL25077089	0.89	POLRMT (0.42)	POLRMTMAPK14AKT1AKT2AKT3
SCHEMBL25765554	0.86	POLRMT (0.45)	POLRMTMAPK14
SCHEMBL25076978	0.84	POLRMT (0.45)	POLRMT
SCHEMBL25077637	0.84	POLRMT (0.45)	POLRMT
SCHEMBL25773895	0.84	MAPK14 (0.37)	POLRMTMAPK14AKT1AKT2AKT3
SCHEMBL25077270	0.84	POLRMT (0.45)	POLRMT
SCHEMBL25077218	0.83	POLRMT (0.43)	POLRMTMAPK14
SCHEMBL25077401	0.83	POLRMT (0.43)	POLRMTMAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2023023527-A1	PHOSPHOLIPID COMPOUNDS AND METHODS OF MAKING AND USING THE SAME	GILEAD SCIENCES, INC. (US)	2023-02-23	—	—	WO	disclosed