SCHEMBL25077280

C=N[C@]1(COP(=O)(O)OC[C@H](COCCCCCCCCCCCCCCCC)OCc2ccccc2)O[C@@H](c2ccc3c(N)ncnn23)[C@H](O)[C@@H]1O

nearest known ligand 0.51

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	POLRMT	O00411	1/20	0.51

▸	AKT1	P31749	5/20	0.32

▸	AKT2	P31751	4/20	0.32

▸	AKT3	Q9Y243	4/20	0.32

▸	PIK3R1	P27986	3/20	0.32

▸	PIK3CA	P42336	3/20	0.32

▸	PLCG2	P16885	1/20	0.32

▸	GAB1	Q13480	1/20	0.32

▸	ADK	P55263	1/20	0.31

▸	LPAR1	Q92633	2/20	0.31

▸	LPAR3	Q9UBY5	2/20	0.31

▸	DOT1L	Q8TEK3	1/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL25077245	0.91	POLRMT (0.45)	POLRMTAKT1AKT2AKT3PIK3R1
SCHEMBL25764487	0.91	POLRMT (0.45)	POLRMTAKT1AKT2AKT3PIK3R1
SCHEMBL25077274	0.89	POLRMT (0.50)	POLRMTAKT1AKT2AKT3PIK3R1
SCHEMBL25076978	0.89	POLRMT (0.45)	POLRMT
SCHEMBL26275953	0.88	POLRMT (0.43)	POLRMTAKT1AKT2AKT3PIK3R1
SCHEMBL25077108	0.88	POLRMT (0.43)	POLRMTAKT1AKT2AKT3PIK3R1
SCHEMBL25077637	0.86	POLRMT (0.45)	POLRMT
SCHEMBL25077270	0.86	POLRMT (0.45)	POLRMT
SCHEMBL25077236	0.85	POLRMT (0.45)	POLRMTADKLPAR1LPAR3DOT1L
SCHEMBL25077133	0.85	POLRMT (0.48)	POLRMT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2023023527-A1	PHOSPHOLIPID COMPOUNDS AND METHODS OF MAKING AND USING THE SAME	GILEAD SCIENCES, INC. (US)	2023-02-23	—	—	WO	disclosed