Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 8/20 | 0.52 |
| ▸ | CRBN | Q96SW2 | 8/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30257613 | 1.00 | DDB1 (0.52) | DDB1CRBNALKGAAPDE3B | |
| SCHEMBL30257111 | 0.89 | DDB1 (0.48) | DDB1CRBNALKPDE3BPDE3A | |
| SCHEMBL30257675 | 0.86 | DDB1 (0.64) | DDB1CRBNMEN1KMT2ALMNA | |
| SCHEMBL23120553 | 0.85 | DDB1 (0.50) | DDB1CRBNGAAEPHX2ALDH1A1 | |
| SCHEMBL29817201 | 0.85 | DDB1 (0.50) | DDB1CRBNGAAEPHX2ALDH1A1 | |
| SCHEMBL31255309 | 0.85 | DDB1 (0.49) | DDB1CRBNALKGAAPDE3B | |
| SCHEMBL24530703 | 0.84 | DDB1 (0.50) | DDB1CRBNGAAMEN1KMT2A | |
| SCHEMBL25079571 | 0.83 | TPSAB1 (0.51) | DDB1CRBNGAAMEN1KMT2A | |
| SCHEMBL30525413 | 0.83 | CRBN (0.55) | DDB1CRBNALDH1A1LMNAUSP30 | |
| SCHEMBL29265203 | 0.83 | CRBN (0.55) | DDB1CRBNALDH1A1LMNAUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023531-A1 | ESTROGEN RECEPTOR DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2023-02-23 | — | — | WO | disclosed |