Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 9/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 9/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 7/20 | 0.51 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.41 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25093280 | 0.84 | GSK3B (0.40) | CYP2D6 | |
| SCHEMBL13093644 | 0.83 | PDE10A (0.40) | ALDH1A1 | |
| SCHEMBL26675031 | 0.81 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| SCHEMBL14805866 | 0.77 | CYP11B2 (0.50) | CHRNB2CHRNA4CHRNA7CYP2A6ALDH1A1 | |
| SCHEMBL12026514 | 0.75 | CYP11B2 (0.51) | CHRNB2CHRNA4CHRNA7CYP2A6ALDH1A1 | |
| SCHEMBL23982003 | 0.75 | GPR119 (0.52) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| SCHEMBL13841172 | 0.74 | CYP11B2 (0.55) | CHRNB2CHRNA4CHRNA7CYP2A6ALDH1A1 | |
| SCHEMBL28989369 | 0.73 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 | |
| SCHEMBL13841158 | 0.73 | CYP11B2 (0.57) | CHRNB2CHRNA4CHRNA7CYP2A6ALDH1A1 | |
| SCHEMBL3956949 | 0.71 | TP53 (0.56) | CHRNB2CHRNA4CHRNA7CYP2A6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11648254-B2 | Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling | KUMQUAT BIOSCIENCES INC. (US) | 2023-05-16 | — | — | US | disclosed |
| US-11648254-B2 | Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling | KUMQUAT BIOSCIENCES INC. (US) | 2023-05-16 | — | — | US | disclosed |
| US-20230064360-A1 | HETEROCYCLES AND USES THEREOF | KUMQUAT BIOSCIENCES INC. | 2023-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11648254-B2 | Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling | KRAS, NRAS, BRAF | CHRNB2 3711/4885CHRNA4 4681/4885CHRNA7 4665/4885 |
| US-20230064360-A1 | HETEROCYCLES AND USES THEREOF | KRAS, HRAS, TP53 | CHRNB2 4426/4885CHRNA4 4815/4885CHRNA7 4753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.